Faruk Uguz1, Erdem Onder Sonmez2, Mine Sahingoz3, Zeynel Gokmen4, Mustafa Basaran5, Kazim Gezginc6, Gulsum Sonmez7, Nazmiye Kaya8, Emre Yilmaz9, Sami Sait Erdem10, Hasan Haluk Dulger11, Humeyra Cicekler12, Erkan Tasyurek13. 1. Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: farukuguz@gmail.com. 2. Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: eondersonmez@gmail.com. 3. Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: drpekalkan@hotmail.com. 4. Department of Neonatology, Konya Research and Training Hospital, Konya, Turkey. Electronic address: zggokmen@yahoo.com. 5. Department of Obstetrics and Gynecology, Konya Research and Training Hospital, Konya, Turkey. Electronic address: mustafabasaran@ymail.com. 6. Department of Obstetrics and Gynecology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: kazimgezginc@hotmail.com. 7. Department of Neonatology, Konya Research and Training Hospital, Konya, Turkey. Electronic address: dr_gulsumyilmaz@hotmail.com. 8. Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: nazmiyekaya@gmail.com. 9. Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: emrena14@gmail.com. 10. Department of Biochemistry, Konya Research and Training Hospital, Konya, Turkey. Electronic address: serdem1505@yahoo.com. 11. Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: halukdulger@yahoo.com. 12. Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: drhcicekler@hotmail.com. 13. Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. Electronic address: erkan1452@mynet.com.
Abstract
OBJECTIVE: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-α) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-α levels in newborn infants of women with and without OCD. METHODS: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-α level was obtained from the umbilical cord during delivery. RESULTS: Cord blood TNF-α levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-α levels in newborn infants of women with OCD. CONCLUSION: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-α.
OBJECTIVE: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-α) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-α levels in newborn infants of women with and without OCD. METHODS: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-α level was obtained from the umbilical cord during delivery. RESULTS: Cord blood TNF-α levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-α levels in newborn infants of women with OCD. CONCLUSION: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-α.