Aliaksei Kisialiou1, Rodolfo Grella2, Albino Carrizzo3, Giordana Pelone2, Michelangelo Bartolo4, Chiara Zucchella5, Francesco Rozza6, Giovanni Grillea7, Claudio Colonnese8, Luigi Formisano9, Maria Lembo10, Annibale A Puca11, Carmine Vecchione12. 1. Clinical Epidemiology & Biostatistics Unit, Innomed Srl, Località Camerelle, Pozzilli, IS, Italy. 2. Stroke Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy. 3. Vascular Physiopathology Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy. 4. NeuroRehabilitation Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy. 5. NeuroRehabilitation Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. 6. Department of Medicine and Surgery, University of Salerno, Salerno, Italy. 7. Diagnostical & Therapeutical NeuroRadiology Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy. 8. Diagnostical & Therapeutical NeuroRadiology Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy; Department of Neuroradiology, Umberto I Hospital, University Sapienza, Rome, Italy. 9. Department of Science and Technology, University of Sannio, Benevento, Italy. 10. Department of Medicine and Surgery, University of Rome, La Sapienza, Italy. 11. IRCCS MultiMedica, Milan, Italy; Department of Medicine and Surgery, University of Salerno, Salerno, Italy. 12. Vascular Physiopathology Unit, IRCCS INM Neuromed, Pozzilli, IS, Italy; Department of Medicine and Surgery, University of Salerno, Salerno, Italy. Electronic address: vecchione@neuromed.it.
Abstract
BACKGROUND: Acute ischemic stroke (AIS) is influenced by gender, age, and the brain site affected. Better characterization of AIS is necessary for improving guidelines, prevention, and destination of resources. METHODS: Demographics, prestroke conditions, etiology, subtypes, specific hospital outcome, clinical and laboratory parameters, and mortality rates were prospectively registered in 105 southern Italian patients. RESULTS: AIS became more frequent in women than in men after age 65 years. Cryptogenic AIS decreased with age independently of sex and lesion site. Cerebellum-brainstem stroke was more prevalent in men, whereas anterior AIS was more frequent in women. There were no overall differences in 6- and 12-month survival rates based on site or sex; however, mortality rates were high after age 80 years. Chronic kidney disease was more frequent in patients with cerebellum-brainstem stroke, and its prevalence increased significantly with age independently of sex. Association of AIS with arterial hypertension, diabetes, and previous myocardial infarction increased with age, whereas that with active smoking decreased with age, independently of sex and site. CONCLUSION: Specific AIS etiology and blood characteristics associated independently to the youngest and oldest AIS patients, respectively. Chronic kidney disease was a specific predictor of cerebellum-brainstem AIS. AIS mortality showed peculiar association with the oldest patients.
BACKGROUND: Acute ischemic stroke (AIS) is influenced by gender, age, and the brain site affected. Better characterization of AIS is necessary for improving guidelines, prevention, and destination of resources. METHODS: Demographics, prestroke conditions, etiology, subtypes, specific hospital outcome, clinical and laboratory parameters, and mortality rates were prospectively registered in 105 southern Italian patients. RESULTS: AIS became more frequent in women than in men after age 65 years. Cryptogenic AIS decreased with age independently of sex and lesion site. Cerebellum-brainstem stroke was more prevalent in men, whereas anterior AIS was more frequent in women. There were no overall differences in 6- and 12-month survival rates based on site or sex; however, mortality rates were high after age 80 years. Chronic kidney disease was more frequent in patients with cerebellum-brainstem stroke, and its prevalence increased significantly with age independently of sex. Association of AIS with arterial hypertension, diabetes, and previous myocardial infarction increased with age, whereas that with active smoking decreased with age, independently of sex and site. CONCLUSION: Specific AIS etiology and blood characteristics associated independently to the youngest and oldest AIS patients, respectively. Chronic kidney disease was a specific predictor of cerebellum-brainstem AIS. AIS mortality showed peculiar association with the oldest patients.