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Literature DB >> 24479797

Interrelationships of circulating tumor cells with metastasis and thrombosis: role of microRNAs.

Junli Xue, Victoria K Xie, Peipei Wang, Jiujie Cui, Yong Gao, Zhimin Lu¹.

Abstract

Metastasis and thrombosis are serious threats to cancer patients and generally associated with poor prognosis. The elusive mechanisms underlying the pathogenesis of metastasis and thrombosis have been subjects of extensive investigations. The presence of circulating tumor cells (CTCs) is closely related to tumor metastasis, and these cells play an important role in thrombosis in cancer patients. In this review, we describe the latest findings on the role of CTCs in tumor metastasis and cancer-related thrombosis and the regulatory role of microRNAs in CTCs and thrombosis. Additionally, we discuss anticoagulant-based strategies for the prevention of thrombosis and reduction of cancer metastasis and the potential to translate current knowledge on these strategies to the treatment of cancer.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
MicroRNAs

Year: 2014 PMID： 24479797 PMCID： PMC4448963 DOI： 10.2174/1381612820666140128220152

Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116

116 in total

1. MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling.

Authors: J-P Zhang; C Zeng; L Xu; J Gong; J-H Fang; S-M Zhuang
Journal: Oncogene Date: 2013-09-09 Impact factor: 9.867

2. A simple multicolor flow cytometry protocol for detection and molecular characterization of circulating tumor cells in epithelial cancers.

Authors: Tsvetana Hristozova; Robert Konschak; Volker Budach; Ingeborg Tinhofer
Journal: Cytometry A Date: 2012-03-21 Impact factor: 4.355

3. A novel estrogen receptor-microRNA 190a-PAR-1-pathway regulates breast cancer progression, a finding initially suggested by genome-wide analysis of loci associated with lymph-node metastasis.

Authors: Hou-Wei Chu; Chun-Wen Cheng; Wen-Cheng Chou; Ling-Yueh Hu; Hsiao-Wei Wang; Chia-Ni Hsiung; Huan-Ming Hsu; Pei-Ei Wu; Ming-Feng Hou; Chen-Yang Shen; Jyh-Cherng Yu
Journal: Hum Mol Genet Date: 2013-09-05 Impact factor: 6.150

Review 4. Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy.

Authors: Min Shi; Jiujie Cui; Keping Xie
Journal: Curr Drug Targets Date: 2013-09 Impact factor: 3.465

5. Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.

Authors: Matthew G Krebs; Jian-Mei Hou; Robert Sloane; Lee Lancashire; Lynsey Priest; Daisuke Nonaka; Tim H Ward; Alison Backen; Glen Clack; Andrew Hughes; Malcolm Ranson; Fiona H Blackhall; Caroline Dive
Journal: J Thorac Oncol Date: 2012-02 Impact factor: 15.609

6. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.

Authors: Ana M Gil-Bernabé; Spela Ferjancic; Monika Tlalka; Lei Zhao; Philip D Allen; Jae Hong Im; Karla Watson; Sally A Hill; Ali Amirkhosravi; John L Francis; Jeffrey W Pollard; Wolfram Ruf; Ruth J Muschel
Journal: Blood Date: 2012-02-10 Impact factor: 22.113

7. VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.

Authors: A A Kondkar; M S Bray; S M Leal; S Nagalla; D J Liu; Y Jin; J F Dong; Q Ren; S W Whiteheart; C Shaw; P F Bray
Journal: J Thromb Haemost Date: 2009-11-23 Impact factor: 5.824

Review 8. Advances of lab-on-a-chip in isolation, detection and post-processing of circulating tumour cells.

Authors: Ling Yu; Shu Rui Ng; Yang Xu; Hua Dong; Ying Jun Wang; Chang Ming Li
Journal: Lab Chip Date: 2013-06-17 Impact factor: 6.799

9. Imaging cytometry for counting circulating tumor cells: comparative analysis of the CellSearch vs ImageStream systems.

Authors: Natividad López-Riquelme; Alfredo Minguela; Flori Villar-Permuy; Daniel Ciprian; Adela Castillejo; María-Rocio Álvarez-López; José-Luis Soto
Journal: APMIS Date: 2013-03-20 Impact factor: 3.205