Literature DB >> 24479793

Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology.

Natalay Kouprina1, Alexey N Tomilin, Hiroshi Masumoto, William C Earnshaw, Vladimir Larionov.   

Abstract

INTRODUCTION: Human artificial chromosomes (HACs) have several advantages over viruses as gene delivery vectors, including stable episomal maintenance in a single copy and the ability to carry large gene inserts. AREAS COVERED: In this review, we summarise recent work on gene transfer into mammalian cells using the HACs. HACs allow therapeutic transgenes to be expressed in target cells under conditions that recapitulate the physiological regulation of endogenous loci. EXPERT OPINION: Based on the published data, the HAC vectors have a great potential for gene therapy, regenerative medicine, screening of anticancer drugs and biotechnology.

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Year:  2014        PMID： 24479793     DOI： 10.1517/17425247.2014.882314

Source DB:  PubMed          Journal:  Expert Opin Drug Deliv        ISSN： 1742-5247            Impact factor:   6.648


  33 in total

Review 1.  Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

Authors:  Narumi Uno; Satoshi Abe; Mitsuo Oshimura; Yasuhiro Kazuki
Journal:  J Hum Genet       Date:  2017-11-27       Impact factor: 3.172

2.  Human artificial chromosomes for future biomedicine.

Authors:  Robert L Katona
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

Review 3.  Using human artificial chromosomes to study centromere assembly and function.

Authors:  Oscar Molina; Natalay Kouprina; Hiroshi Masumoto; Vladimir Larionov; William C Earnshaw
Journal:  Chromosoma       Date:  2017-07-07       Impact factor: 4.316

Review 4.  Pluripotent stem cell-based gene therapy approach: human de novo synthesized chromosomes.

Authors:  Sergey A Sinenko; Sergey V Ponomartsev; Alexey N Tomilin
Journal:  Cell Mol Life Sci       Date:  2020-10-03       Impact factor: 9.261

5.  Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice.

Authors:  Mikhail Liskovykh; Sergey Ponomartsev; Elena Popova; Michael Bader; Natalay Kouprina; Vladimir Larionov; Natalia Alenina; Alexey Tomilin
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

Review 6.  De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.

Authors:  Robert L Katona
Journal:  Chromosome Res       Date:  2015-02       Impact factor: 5.239

Review 7.  Human artificial chromosomes for Duchenne muscular dystrophy and beyond: challenges and hopes.

Authors:  Francesco Saverio Tedesco
Journal:  Chromosome Res       Date:  2015-02       Impact factor: 5.239

Review 8.  Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.

Authors:  Natalay Kouprina; Vladimir Larionov
Journal:  Chromosoma       Date:  2016-04-26       Impact factor: 4.316

9.  Diatom centromeres suggest a mechanism for nuclear DNA acquisition.

Authors:  Rachel E Diner; Chari M Noddings; Nathan C Lian; Anthony K Kang; Jeffrey B McQuaid; Jelena Jablanovic; Josh L Espinoza; Ngocquynh A Nguyen; Miguel A Anzelmatti; Jakob Jansson; Vincent A Bielinski; Bogumil J Karas; Christopher L Dupont; Andrew E Allen; Philip D Weyman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-03       Impact factor: 11.205

10.  Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.

Authors:  Hee-Sheung Lee; Mar Carmena; Mikhail Liskovykh; Emma Peat; Jung-Hyun Kim; Mitsuo Oshimura; Hiroshi Masumoto; Marie-Paule Teulade-Fichou; Yves Pommier; William C Earnshaw; Vladimir Larionov; Natalay Kouprina
Journal:  Cancer Res       Date:  2018-08-30       Impact factor: 12.701
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