Literature DB >> 24478545

Prevalence of +405G>C,-1154G>A Vascular Endothelial Growth Factor Polymorphism in Breast Cancer.

Rani James1, G Ramesh1, Lakshmi Krishnamoorthy1, Rahul Bhagat1, Shilpa Chadaga1, Vijayalaxmi Deshmane2, Girija Ramaswamy1.   

Abstract

Vascular endothelial growth factor (VEGF) plays an important role in the development of Breast Cancer. The aim of this study was to investigate the association of polymorphisms in the VEGF gene on prognosis of Breast Cancer patients. This study comprised 200 patients with histologically confirmed cases of Breast cancer and 200 controls. Genotyping of the VEGF gene polymorphisms at +405G>C,-1154G>A, were performed by PCR-RFLP analysis. Preoperative plasma VEGF levels were determined by ELISA. Amongst both cases and controls, the genotypic distribution of the individual SNPs were all in Hardy-Weinberg equilibrium. Mean VEGF level was significantly elevated in cases compared to controls (t = 8.248; P < 0.001). No significant association was found between +405G>C,-1154G>A VEGF polymorphism and Breast Cancer. Logistic regression analysis revealed that 405GG & 1154GG were associated with higher levels of VEGF.

Entities:  

Keywords:  Breast cancer; ELISA; Genotype; Plasma VEGF; VEGF polymorphism

Year:  2013        PMID： 24478545      PMCID： PMC3903925          DOI： 10.1007/s12291-013-0307-2

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  30 in total

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