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Literature DB >> 24478032

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.

Camilla Pramfalk¹, Tiffany A Melhuish, David Wotton, Zhao-Yan Jiang, Mats Eriksson, Paolo Parini.

Abstract

Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2. Tgif1 could also block the induction of the SOAT2 promoter activity by hepatocyte nuclear factor 1α and 4α. Women have ∼ 30% higher hepatic TGIF1 mRNA compared with men. Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism.

Entities: Chemical Gene Species

Keywords: hepatocyte nuclear factor 1α and 4α; human; liver; triglyceride

Mesh：

Substances：

Year: 2014 PMID： 24478032 PMCID： PMC3966704 DOI： 10.1194/jlr.M045922

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

39 in total

1. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

Authors: Ryan E Temel; Richard G Lee; Kathryn L Kelley; Matthew A Davis; Ramesh Shah; Janet K Sawyer; Martha D Wilson; Lawrence L Rudel
Journal: J Lipid Res Date: 2005-09-08 Impact factor: 5.922

2. Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.

Authors: Bao-Liang Song; Can-Hua Wang; Xiao-Min Yao; Li Yang; Wen-Jing Zhang; Zhen-Zhen Wang; Xiao-Nan Zhao; Jin-Bo Yang; Wei Qi; Xin-Ying Yang; Kenji Inoue; Zhi-Xin Lin; Hui-Zhan Zhang; Tatsuhiko Kodama; Catherine C Y Chang; Yin-Kun Liu; Ta-Yuan Chang; Bo-Liang Li
Journal: Biochem J Date: 2006-03-15 Impact factor: 3.857

3. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.

Authors: T Tanaka; S Jiang; H Hotta; K Takano; H Iwanari; K Sumi; K Daigo; R Ohashi; M Sugai; C Ikegame; H Umezu; Y Hirayama; Y Midorikawa; Y Hippo; A Watanabe; Y Uchiyama; G Hasegawa; Pc Reid; H Aburatani; T Hamakubo; J Sakai; M Naito; T Kodama
Journal: J Pathol Date: 2006-04 Impact factor: 7.996

4. Relation of plasma phospholipid and cholesterol ester fatty acid composition to carotid artery intima-media thickness: the Atherosclerosis Risk in Communities (ARIC) Study.

Authors: J Ma; A R Folsom; L Lewis; J H Eckfeldt
Journal: Am J Clin Nutr Date: 1997-02 Impact factor: 7.045

5. Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.

Authors: Zhao-Yan Jiang; Chong-Yi Jiang; Lei Wang; Jian-Cheng Wang; Sheng-Dao Zhang; Curt Einarsson; Mats Eriksson; Tian-Quan Han; Paolo Parini; Gösta Eggertsen
Journal: Biochem Biophys Res Commun Date: 2008-12-09 Impact factor: 3.575

6. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

Authors: J Mark Brown; Thomas A Bell; Heather M Alger; Janet K Sawyer; Thomas L Smith; Kathryn Kelley; Ramesh Shah; Martha D Wilson; Matthew A Davis; Richard G Lee; Mark J Graham; Rosanne M Crooke; Lawrence L Rudel
Journal: J Biol Chem Date: 2008-02-14 Impact factor: 5.157

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.

1. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

2. Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.

3. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.

4. Relation of plasma phospholipid and cholesterol ester fatty acid composition to carotid artery intima-media thickness: the Atherosclerosis Risk in Communities (ARIC) Study.

5. Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.

6. Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

7. A transcriptional hierarchy involved in mammalian cell-type specification.

8. MEIS and PBX homeobox proteins in ovarian cancer.

9. Maternal Tgif is required for vascularization of the embryonic placenta.

10. A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.

1. Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.

2. Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.

3. Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies.

4. Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix.

5. Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.