INTRODUCTION: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different. METHODS: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓. RESULTS: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑. CONCLUSIONS: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other.
INTRODUCTION: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different. METHODS: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓. RESULTS: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑. CONCLUSIONS: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other.
Authors: Dominique Laude; Jean-Luc Elghozi; Arlette Girard; Elisabeth Bellard; Malika Bouhaddi; Paolo Castiglioni; Catherine Cerutti; Andrei Cividjian; Marco Di Rienzo; Jacques-Olivier Fortrat; Ben Janssen; John M Karemaker; Georges Lefthériotis; Gianfranco Parati; Pontus B Persson; Alberto Porta; Luc Quintin; Jacques Regnard; Heinz Rüdiger; Harald M Stauss Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-09-18 Impact factor: 3.619
Authors: R Virtanen; A Jula; H Huikuri; T Kuusela; H Helenius; A Ylitalo; L-M Voipio-Pulkki; H Kauma; Y A Kesäniemi; J Airaksinen Journal: J Hum Hypertens Date: 2004-04 Impact factor: 3.012
Authors: Myles W O'Brien; Jarrett A Johns; Tristan W Dorey; Ryan J Frayne; Jonathon R Fowles; Said Mekary; Derek S Kimmerly Journal: Clin Auton Res Date: 2019-10-12 Impact factor: 4.435