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Literature DB >> 24477653

miR-200b as a prognostic factor targets multiple members of RAB family in glioma.

Qing Liu¹, Hailin Tang, Xiaoping Liu, Yiwei Liao, Haoyu Li, Zijin Zhao, Xianrui Yuan, Weixi Jiang.

Abstract

miR-200b is a tumor suppressor in multiple tumors including gastric cancer, breast cancer, ovarian cancer and glioma. In this study, we detected the expression of miR-200b and analyzed its correlation with clinicopathological parameters in glioma tissues. miR-200b was downregulated in glioma tissues. And its downexpression was correlated with poor prognosis in gliomas. Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be novel targets of miR-200b. The direct suppression of RAB21, RAB23, RAB18 and RAB3B expressions by miR-200b was revealed by luciferase reporter assay, quantitative RT-PCR analysis and Western blot. Furthermore, the overall survival of patients with different expression of RABs was analyzed. The expression of RAB21, RAB23, RAB18 and RAB3B was related to the prognosis and histopathology of glioma. The patients who had the upregulation of all the four RABs had the worst outcome; those who had the downregulation of all RABs had the best outcome (p<0.001). miR-200b was a potential biomarker for glioma prognosis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24477653 DOI： 10.1007/s12032-014-0859-x

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

29 in total

1. The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients.

Authors: Susanna Leskelä; Luis J Leandro-García; Marta Mendiola; Jorge Barriuso; Lucía Inglada-Pérez; Iván Muñoz; Beatriz Martínez-Delgado; Andrés Redondo; Javier de Santiago; Mercedes Robledo; David Hardisson; Cristina Rodríguez-Antona
Journal: Endocr Relat Cancer Date: 2010-12-21 Impact factor: 5.678

2. Rab18 and Rab43 have key roles in ER-Golgi trafficking.

Authors: Selma Y Dejgaard; Ayesha Murshid; Aysegül Erman; Ozge Kizilay; David Verbich; Robert Lodge; Kurt Dejgaard; Thi Bach Nga Ly-Hartig; Rainer Pepperkok; Jeremy C Simpson; John F Presley
Journal: J Cell Sci Date: 2008-07-29 Impact factor: 5.285

3. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

Authors: Xiaona You; Fabao Liu; Tao Zhang; Yinghui Li; Lihong Ye; Xiaodong Zhang
Journal: Carcinogenesis Date: 2013-03-07 Impact factor: 4.944

4. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.

Authors: Manav Korpal; Esther S Lee; Guohong Hu; Yibin Kang
Journal: J Biol Chem Date: 2008-04-14 Impact factor: 5.157

5. Characterization of Rab18, a lipid droplet-associated small GTPase.

Authors: Sally Martin; Robert G Parton
Journal: Methods Enzymol Date: 2008 Impact factor: 1.600

6. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.

Authors: An Hendrix; Raija Sormunen; Wendy Westbroek; Kathleen Lambein; Hannelore Denys; Gwen Sys; Geert Braems; Rudy Van den Broecke; Veronique Cocquyt; Christian Gespach; Marc Bracke; Olivier De Wever
Journal: Int J Cancer Date: 2013-03-07 Impact factor: 7.396

7. Epithelial-mesenchymal transition-related microRNA-200s regulate molecular targets and pathways in renal cell carcinoma.

Authors: Hirofumi Yoshino; Hideki Enokida; Toshihiko Itesako; Shuichi Tatarano; Takashi Kinoshita; Miki Fuse; Satoko Kojima; Masayuki Nakagawa; Naohiko Seki
Journal: J Hum Genet Date: 2013-05-02 Impact factor: 3.172

8. A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.

Authors: S Hooper; C Gaggioli; E Sahai
Journal: Br J Cancer Date: 2009-12-01 Impact factor: 7.640

9. miR-200b targets GATA-4 during cell growth and differentiation.

Authors: Chun-Xia Yao; Qing-Xia Wei; Yan-Yan Zhang; Wei-Ping Wang; Li-Xiang Xue; Fen Yang; Shu-Feng Zhang; Cheng-Juan Xiong; Wen-Yan Li; Zhi-Ru Wei; Yunzeng Zou; Ming-Xi Zang
Journal: RNA Biol Date: 2013-04-01 Impact factor: 4.652

10. The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.

Authors: Maricica Pacurari; Joseph B Addison; Naveen Bondalapati; Ying-Wooi Wan; Dajie Luo; Yong Qian; Vincent Castranova; Alexey V Ivanov; Nancy Lan Guo
Journal: Int J Oncol Date: 2013-05-27 Impact factor: 5.650

18 in total

10. miR‑367‑3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.

Authors: Wei Du; Dong Li; Jianhao Xie; Ping Tang
Journal: Oncol Rep Date: 2021-07-19 Impact factor: 3.906

miR-200b as a prognostic factor targets multiple members of RAB family in glioma.

1. The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients.

2. Rab18 and Rab43 have key roles in ER-Golgi trafficking.

3. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.

4. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.

5. Characterization of Rab18, a lipid droplet-associated small GTPase.

6. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.

7. Epithelial-mesenchymal transition-related microRNA-200s regulate molecular targets and pathways in renal cell carcinoma.

8. A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.

9. miR-200b targets GATA-4 during cell growth and differentiation.

10. The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.

Review 1. Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.

2. MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23.

Review 3. Rab23 activities and human cancer-emerging connections and mechanisms.

4. Effect of Licochalcone-A Combined with Rab23 Gene on Proliferation of Glioma U251 Cells.

5. miR-135b contributes to the radioresistance by targeting GSK3β in human glioblastoma multiforme cells.

Review 6. The role of the small GTPase Rab31 in cancer.

7. MiRNA-200b Regulates RMP7-Induced Increases in Blood-Tumor Barrier Permeability by Targeting RhoA and ROCKII.

Review 8. MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours.

9. miR-367 promotes proliferation and stem-like traits in medulloblastoma cells.

10. miR‑367‑3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.