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Literature DB >> 24477642

Signalling between microvascular endothelium and cardiomyocytes through neuregulin.

Abstract

Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.

Entities: Disease

Keywords: ErbB; Heart; Heterocellular communication; Neuregulin

Mesh：

Substances：
Neuregulins

Year: 2014 PMID： 24477642 PMCID： PMC3989448 DOI： 10.1093/cvr/cvu021

Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787

154 in total

1. Programmed cell death in the developing heart: regulation by BMP4 and FGF2.

Authors: Z Zhao; S A Rivkees
Journal: Dev Dyn Date: 2000-04 Impact factor: 3.780

2. Ligand discrimination in signaling through an ErbB4 receptor homodimer.

Authors: C Sweeney; C Lai; D J Riese; A J Diamonti; L C Cantley; K L Carraway
Journal: J Biol Chem Date: 2000-06-30 Impact factor: 5.157

3. Nrg1 reverse signaling in cortical pyramidal neurons.

Authors: Sandra Peregrin Pedrique; Pietro Fazzari
Journal: J Neurosci Date: 2010-11-10 Impact factor: 6.167

4. Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro.

Authors: N V Patel; M J Acarregui; J M Snyder; J M Klein; M X Sliwkowski; J A Kern
Journal: Am J Respir Cell Mol Biol Date: 2000-04 Impact factor: 6.914

5. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors.

Authors: S Rohrbach; X Yan; E O Weinberg; F Hasan; J Bartunek; M A Marchionni; B H Lorell
Journal: Circulation Date: 1999-07-27 Impact factor: 29.690

6. Neuregulin-1 promotes formation of the murine cardiac conduction system.

Authors: Stacey Rentschler; Jennifer Zander; Kathleen Meyers; David France; Rebecca Levine; George Porter; Scott A Rivkees; Gregory E Morley; Glenn I Fishman
Journal: Proc Natl Acad Sci U S A Date: 2002-07-29 Impact factor: 11.205

7. Neuregulin-1 protects against doxorubicin-induced apoptosis in cardiomyocytes through an Akt-dependent pathway.

Authors: T An; Y Zhang; Y Huang; R Zhang; S Yin; X Guo; Y Wang; C Zou; B Wei; R Lv; Q Zhou; J Zhang
Journal: Physiol Res Date: 2013-04-16 Impact factor: 1.881

8. Prevalence, prospective risk markers, and prognosis associated with the presence of left ventricular diastolic dysfunction in young adults: the coronary artery risk development in young adults study.

Authors: Chintan S Desai; Laura A Colangelo; Kiang Liu; David R Jacobs; Nakela L Cook; Donald M Lloyd-Jones; Kofo O Ogunyankin
Journal: Am J Epidemiol Date: 2012-12-04 Impact factor: 4.897

9. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface.

Authors: Mitchell B Berger; Jeannine M Mendrola; Mark A Lemmon
Journal: FEBS Lett Date: 2004-07-02 Impact factor: 4.124

10. Gene transfer of human neuregulin-1 attenuates ventricular remodeling in diabetic cardiomyopathy rats.

Authors: Bingong Li; Jian Xiao; Yong Li; Jian Zhang; Minghui Zeng
Journal: Exp Ther Med Date: 2013-08-27 Impact factor: 2.447

27 in total

1. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.

Authors: Brian D Polizzotti; Balakrishnan Ganapathy; Stuart Walsh; Sangita Choudhury; Niyatie Ammanamanchi; David G Bennett; Cristobal G dos Remedios; Bernhard J Haubner; Josef M Penninger; Bernhard Kühn
Journal: Sci Transl Med Date: 2015-04-01 Impact factor: 17.956

Signalling between microvascular endothelium and cardiomyocytes through neuregulin.

1. Programmed cell death in the developing heart: regulation by BMP4 and FGF2.

2. Ligand discrimination in signaling through an ErbB4 receptor homodimer.

3. Nrg1 reverse signaling in cortical pyramidal neurons.

4. Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro.

5. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors.

6. Neuregulin-1 promotes formation of the murine cardiac conduction system.

7. Neuregulin-1 protects against doxorubicin-induced apoptosis in cardiomyocytes through an Akt-dependent pathway.

8. Prevalence, prospective risk markers, and prognosis associated with the presence of left ventricular diastolic dysfunction in young adults: the coronary artery risk development in young adults study.

9. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface.

10. Gene transfer of human neuregulin-1 attenuates ventricular remodeling in diabetic cardiomyopathy rats.

1. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.

Review 2. The epicardium as a hub for heart regeneration.

Review 3. Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.

Review 4. Zebrafish heart regeneration: Factors that stimulate cardiomyocyte proliferation.

Review 5. Systems biology approaches to adverse drug effects: the example of cardio-oncology.

Review 6. Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes.

7. Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival.

Review 8. Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening.

Review 9. Molecular mechanisms of heart regeneration.

Review 10. Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy.