Literature DB >> 24476956

Periostin is upregulated in coronary arteriopathy in Kawasaki disease and is a potential diagnostic biomarker.

Rebecca Reindel1, Kwang-Youn A Kim, Susan C Baker, Stanford T Shulman, Elizabeth J Perlman, Mark W Lingen, Cynthia Trevenen, Anne H Rowley.   

Abstract

Periostin was upregulated 11-fold in acute and chronic Kawasaki disease coronary arteries compared with controls (P = 0.003). Kawasaki disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.

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Year:  2014        PMID: 24476956      PMCID: PMC4086943          DOI: 10.1097/INF.0000000000000233

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN: 0891-3668            Impact factor:   2.129


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