| Literature DB >> 24476042 |
Danyang Zhu1, Kedar N Baryal, Surya Adhikari, Jianglong Zhu.
Abstract
An approach for direct synthesis of biologically significant 2-deoxy-β-glycosides has been developed via O-alkylation of a variety of 2-deoxy-sugar-derived anomeric alkoxides using challenging secondary triflates as electrophiles. It was found a free hydroxyl group at C3 of the 2-deoxy-sugar-derived lactols is required in order to achieve synthetically efficient yields. This method has also been applied to the convergent synthesis of a 2-deoxy-β-tetrasaccharide.Entities:
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Year: 2014 PMID： 24476042 DOI： 10.1021/ja4116956
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419