Ali Ghorbani1, Mahmoud Rafieian-Kopaei2, Hamid Nasri3. 1. Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. 3. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Abstract
BACKGROUND: Hypertension (HTN) is a very common disorder with a substantial impact on public health because of its complications. OBJECTIVES: To study the association of serum lipoprotein(a) [Lp(a)] elevation with essential hypertension (eHTN). PATIENTS AND METHODS: This study was conducted on a group of essential hypertensive patients. Laboratory exams consisting of serum creatinine and Lp(a) were measured. RESULTS: Ninety five essential hypertensive patients were enrolled to the study. Serum LP (a) in patients was 46.5±20. In patients an inverse correlation between serum Lp(a) andcreatinine clearance was seen (r = -0.175 p<0.05). There was a significant correlation between serum Lp(a) and age (r =0.191 p<0.05) or duration of HTN (known duration of hypertension period) (r =0.362 p<0.05). CONCLUSIONS: Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.
BACKGROUND:Hypertension (HTN) is a very common disorder with a substantial impact on public health because of its complications. OBJECTIVES: To study the association of serum lipoprotein(a) [Lp(a)] elevation with essential hypertension (eHTN). PATIENTS AND METHODS: This study was conducted on a group of essential hypertensivepatients. Laboratory exams consisting of serum creatinine and Lp(a) were measured. RESULTS: Ninety five essential hypertensivepatients were enrolled to the study. Serum LP (a) in patients was 46.5±20. In patients an inverse correlation between serum Lp(a) andcreatinine clearance was seen (r = -0.175 p<0.05). There was a significant correlation between serum Lp(a) and age (r =0.191 p<0.05) or duration of HTN (known duration of hypertension period) (r =0.362 p<0.05). CONCLUSIONS: Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.
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