Mehdi Nematbakhsh1, Farzaneh Ashrafi2, Zahra Pezeshki3, Zahra Fatahi4, Fariborz Kianpoor3, Mohammad-Hossein Sanei5, Ardeshir Talebi5. 1. Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran. ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. ; Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran. ; Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran. 4. Clinical Pathologist, Isfahan, Iran. 5. Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
BACKGROUND: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. OBJECTIVES: To found, which of the toxicities is the first side effect of CP. MATERIALS AND METHODS: we conducted a pilot research on 12 adult male Wistar rats. RESULTS: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue. CONCLUSIONS: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model.
BACKGROUND:Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. OBJECTIVES: To found, which of the toxicities is the first side effect of CP. MATERIALS AND METHODS: we conducted a pilot research on 12 adult male Wistar rats. RESULTS: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue. CONCLUSIONS: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model.