Literature DB >> 24474434

Nudging guideline-concordant antibiotic prescribing: a randomized clinical trial.

Daniella Meeker1, Tara K Knight2, Mark W Friedberg3, Jeffrey A Linder4, Noah J Goldstein5, Craig R Fox5, Alan Rothfeld6, Guillermo Diaz7, Jason N Doctor2.   

Abstract

IMPORTANCE: "Nudges" that influence decision making through subtle cognitive mechanisms have been shown to be highly effective in a wide range of applications, but there have been few experiments to improve clinical practice.
OBJECTIVE: To investigate the use of a behavioral "nudge" based on the principle of public commitment in encouraging the judicious use of antibiotics for acute respiratory infections (ARIs). DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial in 5 outpatient primary care clinics. A total of 954 adults had ARI visits during the study timeframe: 449 patients were treated by clinicians randomized to the posted commitment letter (335 in the baseline period, 114 in the intervention period); 505 patients were treated by clinicians randomized to standard practice control (384 baseline, 121 intervention).
INTERVENTIONS: The intervention consisted of displaying poster-sized commitment letters in examination rooms for 12 weeks. These letters, featuring clinician photographs and signatures, stated their commitment to avoid inappropriate antibiotic prescribing for ARIs. MAIN OUTCOMES AND MEASURES: Antibiotic prescribing rates for antibiotic-inappropriate ARI diagnoses in baseline and intervention periods, adjusted for patient age, sex, and insurance status.
RESULTS: Baseline rates were 43.5% and 42.8% for control and poster, respectively. During the intervention period, inappropriate prescribing rates increased to 52.7% for controls but decreased to 33.7% in the posted commitment letter condition. Controlling for baseline prescribing rates, we found that the posted commitment letter resulted in a 19.7 absolute percentage reduction in inappropriate antibiotic prescribing rate relative to control (P = .02). There was no evidence of diagnostic coding shift, and rates of appropriate antibiotic prescriptions did not diminish over time. CONCLUSIONS AND RELEVANCE: Displaying poster-sized commitment letters in examination rooms decreased inappropriate antibiotic prescribing for ARIs. The effect of this simple, low-cost intervention is comparable in magnitude to costlier, more intensive quality-improvement efforts. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01767064.

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Year:  2014        PMID: 24474434      PMCID: PMC4648560          DOI: 10.1001/jamainternmed.2013.14191

Source DB:  PubMed          Journal:  JAMA Intern Med        ISSN: 2168-6106            Impact factor:   21.873


  29 in total

1.  Changing provider behavior: an overview of systematic reviews of interventions.

Authors:  J M Grimshaw; L Shirran; R Thomas; G Mowatt; C Fraser; L Bero; R Grilli; E Harvey; A Oxman; M A O'Brien
Journal:  Med Care       Date:  2001-08       Impact factor: 2.983

Review 2.  Changing physicians' behavior: what works and thoughts on getting more things to work.

Authors:  Jeremy M Grimshaw; Martin P Eccles; Anne E Walker; Ruth E Thomas
Journal:  J Contin Educ Health Prof       Date:  2002       Impact factor: 1.355

3.  Antibiotics and respiratory infections: are patients more satisfied when expectations are met?

Authors:  R M Hamm; R J Hicks; D A Bemben
Journal:  J Fam Pract       Date:  1996-07       Impact factor: 0.493

Review 4.  Patterns of intra-cluster correlation from primary care research to inform study design and analysis.

Authors:  Geoffrey Adams; Martin C Gulliford; Obioha C Ukoumunne; Sandra Eldridge; Susan Chinn; Michael J Campbell
Journal:  J Clin Epidemiol       Date:  2004-08       Impact factor: 6.437

5.  Principles of appropriate antibiotic use for treatment of acute respiratory tract infections in adults: background, specific aims, and methods.

Authors:  R Gonzales; J G Bartlett; R E Besser; R J Cooper; J M Hickner; J R Hoffman; M A Sande
Journal:  Ann Intern Med       Date:  2001-03-20       Impact factor: 25.391

6.  Compliance without pressure: the foot-in-the-door technique.

Authors:  J L Freedman; S C Fraser
Journal:  J Pers Soc Psychol       Date:  1966-08

7.  Impact of a limited fluoroquinolone reimbursement policy on antimicrobial prescription claims.

Authors:  M E MacCara; I S Sketris; D G Comeau; S D Weerasinghe
Journal:  Ann Pharmacother       Date:  2001 Jul-Aug       Impact factor: 3.154

8.  The economic burden of non-influenza-related viral respiratory tract infection in the United States.

Authors:  A Mark Fendrick; Arnold S Monto; Brian Nightengale; Matthew Sarnes
Journal:  Arch Intern Med       Date:  2003-02-24

9.  Antibiotic prescribing to adults with sore throat in the United States, 1997-2010.

Authors:  Michael L Barnett; Jeffrey A Linder
Journal:  JAMA Intern Med       Date:  2014-01       Impact factor: 21.873

10.  Optimizing antibiotic prescribing for acute cough in general practice: a cluster-randomized controlled trial.

Authors:  Samuel Coenen; Paul Van Royen; Barbara Michiels; Joke Denekens
Journal:  J Antimicrob Chemother       Date:  2004-07-28       Impact factor: 5.790

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  94 in total

1.  Categorical Risk Perception Drives Variability in Antibiotic Prescribing in the Emergency Department: A Mixed Methods Observational Study.

Authors:  Eili Y Klein; Elena M Martinez; Larissa May; Mustapha Saheed; Valerie Reyna; David A Broniatowski
Journal:  J Gen Intern Med       Date:  2017-06-20       Impact factor: 5.128

2.  Coadministration of co-trimoxazole with sulfonylureas: hypoglycemia events and pattern of use.

Authors:  Alai Tan; Holly M Holmes; Yong-Fang Kuo; Mukaila A Raji; James S Goodwin
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-05-24       Impact factor: 6.053

Review 3.  Novel approaches are needed to develop tomorrow's antibacterial therapies.

Authors:  Brad Spellberg; John Bartlett; Rich Wunderink; David N Gilbert
Journal:  Am J Respir Crit Care Med       Date:  2015-01-15       Impact factor: 21.405

4.  Danger Close: What Opioid Prescribers Can Learn from the Way the Air Force Drops a Bomb.

Authors:  Alex Rich
Journal:  HSS J       Date:  2019-01-14

Review 5.  Antimicrobial Stewardship in the Emergency Department.

Authors:  Michael Pulia; Robert Redwood; Larissa May
Journal:  Emerg Med Clin North Am       Date:  2018-09-06       Impact factor: 2.264

6.  Short-course Antibiotic Therapy-Replacing Constantine Units With "Shorter Is Better".

Authors:  Noah Wald-Dickler; Brad Spellberg
Journal:  Clin Infect Dis       Date:  2019-10-15       Impact factor: 9.079

7.  The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett.

Authors:  Brad Spellberg; David N Gilbert
Journal:  Clin Infect Dis       Date:  2014-09-15       Impact factor: 9.079

8.  Patient satisfaction as a quality metric promotes bad medicine--reply.

Authors:  Daniella Meeker; Mark W Friedberg; Jeffrey A Linder
Journal:  JAMA Intern Med       Date:  2014-08       Impact factor: 21.873

9.  Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial.

Authors:  Adam Sacarny; Michael L Barnett; Jackson Le; Frank Tetkoski; David Yokum; Shantanu Agrawal
Journal:  JAMA Psychiatry       Date:  2018-10-01       Impact factor: 21.596

10.  Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial.

Authors:  Akke Vellinga; Sandra Galvin; Sinead Duane; Aoife Callan; Kathleen Bennett; Martin Cormican; Christine Domegan; Andrew W Murphy
Journal:  CMAJ       Date:  2015-11-16       Impact factor: 8.262

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