INTRODUCTION: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. METHODS: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. RESULTS: The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. CONCLUSIONS: Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients.
INTRODUCTION: The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. METHODS: A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. RESULTS: The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. CONCLUSIONS: Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients.
Authors: Cauê B Scarim; Cleverton R de Andrade; João A da Rosa; Jean L Dos Santos; Chung M Chin Journal: Int J Exp Pathol Date: 2018-10-15 Impact factor: 1.925
Authors: Yanina Sguassero; Cristina B Cuesta; Karen N Roberts; Elizabeth Hicks; Daniel Comandé; Agustín Ciapponi; Sergio Sosa-Estani Journal: PLoS One Date: 2015-10-05 Impact factor: 3.240
Authors: Yanina Sguassero; Karen N Roberts; Guillermina B Harvey; Daniel Comandé; Agustín Ciapponi; Cristina B Cuesta; Camila Aguiar; Ana M de Castro; Emmaría Danesi; Ana L de Andrade; Marta de Lana; Josep M Escribà; Diana L Fabbro; Cloé D Fernandes; María Flores-Chávez; Alejandro M Hasslocher-Moreno; Yves Jackson; Carlos D Lacunza; Girley F Machado-de-Assis; Marisel Maldonado; Wendell S F Meira; Israel Molina; María M Monje-Rumi; Catalina Muñoz-San Martín; Laura Murcia; Cleudson Nery de Castro; Olga Sánchez Negrette; Manuel Segovia; Celeste A N Silveira; Aldo Solari; Mário Steindel; Mirtha L Streiger; Ninfa Vera de Bilbao; Inés Zulantay; Sergio Sosa-Estani Journal: Int J Infect Dis Date: 2018-06-04 Impact factor: 3.623
Authors: Erlane Chaves Freitas; Maria de Fátima Oliveira; Mônica Coelho Andrade; Arduina Sofia Ortet de Barros Vasconcelos; José Damião da Silva Filho; Darlan da Silva Cândido; Laíse dos Santos Pereira; João Paulo Ramalho Correia; José Napoleão Monte da Cruz; Luciano Pamplona de Góes Cavalcanti Journal: Rev Inst Med Trop Sao Paulo Date: 2015 Sep-Oct Impact factor: 1.846
Authors: Abilio Augusto Fragata-Filho; Francisco Faustino França; Claudia da Silva Fragata; Angela Maria Lourenço; Cristiane Castro Faccini; Cristiane Aparecida de Jesus Costa Journal: PLoS Negl Trop Dis Date: 2016-03-14