OBJECTIVE: To review the relationship between lipoprotein (a) [Lp(a)] and other risk factors for cardiovascular disease (CVD) in children and adolescents. DATA SOURCES: This systematic review included studies from 2001 to 2011, a ten-year time period. Epidemiological studies with children and/or adolescents published in English, Portuguese or Spanish and fully available online were included. The searches were performed in Science Direct, PubMed/Medline, BVS (Biblioteca Virtual em Saúde) and Cochrane Library databases, using the following combination of key-words: "lipoprotein a" and "cardiovascular diseases" and "obesity". DATA SYNTHESIS: Overall, 672 studies were obtained but only seven were included. Some studies assessed the family history for CVD. In all of them, Lp(a) levels were increased in patients with family history for CVD. There was also a positive correlation between Lp(a) and LDL-cholesterol, total cholesterol, and apolipoprotein B levels, suggesting an association between Lp(a) levels and the lipid profile. CONCLUSIONS: The evidence that CVD may originate in childhood and adolescence leads to the need for investigating the risk factors during this period in order to propose earlier and possibly more effective interventions to reduce morbidity and mortality rates.
OBJECTIVE: To review the relationship between lipoprotein (a) [Lp(a)] and other risk factors for cardiovascular disease (CVD) in children and adolescents. DATA SOURCES: This systematic review included studies from 2001 to 2011, a ten-year time period. Epidemiological studies with children and/or adolescents published in English, Portuguese or Spanish and fully available online were included. The searches were performed in Science Direct, PubMed/Medline, BVS (Biblioteca Virtual em Saúde) and Cochrane Library databases, using the following combination of key-words: "lipoprotein a" and "cardiovascular diseases" and "obesity". DATA SYNTHESIS: Overall, 672 studies were obtained but only seven were included. Some studies assessed the family history for CVD. In all of them, Lp(a) levels were increased in patients with family history for CVD. There was also a positive correlation between Lp(a) and LDL-cholesterol, total cholesterol, and apolipoprotein B levels, suggesting an association between Lp(a) levels and the lipid profile. CONCLUSIONS: The evidence that CVD may originate in childhood and adolescence leads to the need for investigating the risk factors during this period in order to propose earlier and possibly more effective interventions to reduce morbidity and mortality rates.
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Authors: Y Sáez Meabe; M Lafita Bernar; J P Sáez de Lafuente Chivite; I Narváez Gofinondo; M Vacas Rius; A M Magro López; J D Sagastagoitia Gorostiza; E Molinero de Miguel; J A Iriarte Ezkurdia Journal: An Pediatr (Barc) Date: 2006-03 Impact factor: 1.500
Authors: Thomas O Obisesan; Muktar H Aliyu; Abayomi S Adediran; Vernon Bond; Celia J Maxwell; Charles N Rotimi Journal: Lipids Health Dis Date: 2004-12-16 Impact factor: 3.876
Authors: Thayza de Paula Araújo; Lucas Gabriel Sulino Borges; Weimar Kunz Sebba Barroso; Andrea Araújo Brandão; Eduardo Costa Duarte Barbosa; Audes Diógenes M Feitosa; Marcus Vinícius Bolivar Malachias; Marco Mota Gomes; Celso Amodeo; Rui Manoel Dos Santos Povoa; Paulo César Brandão Veiga Jardim; Renato D Lopes; Sandro Rogério Rodrigues Batista; Priscila Valverde de Oliveira Vitorino Journal: J Clin Hypertens (Greenwich) Date: 2022-06-30 Impact factor: 2.885