Literature DB >> 24473322

A RAG driver on the road to pediatric ALL.

Roland P Kuiper1, Esmé Waanders1.   

Abstract

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

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Year:  2014        PMID： 24473322     DOI： 10.1038/ng.2879

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.

Authors:  Yun Liu; Ramesh Subrahmanyam; Tirtha Chakraborty; Ranjan Sen; Stephen Desiderio
Journal:  Immunity       Date:  2007-10-11       Impact factor: 31.745

Review 2.  Biology, risk stratification, and therapy of pediatric acute leukemias: an update.

Authors:  Ching-Hon Pui; William L Carroll; Soheil Meshinchi; Robert J Arceci
Journal:  J Clin Oncol       Date:  2011-01-10       Impact factor: 44.544

3.  RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

Authors:  Elli Papaemmanuil; Inmaculada Rapado; Yilong Li; Nicola E Potter; David C Wedge; Jose Tubio; Ludmil B Alexandrov; Peter Van Loo; Susanna L Cooke; John Marshall; Inigo Martincorena; Jonathan Hinton; Gunes Gundem; Frederik W van Delft; Serena Nik-Zainal; David R Jones; Manasa Ramakrishna; Ian Titley; Lucy Stebbings; Catherine Leroy; Andrew Menzies; John Gamble; Ben Robinson; Laura Mudie; Keiran Raine; Sarah O'Meara; Jon W Teague; Adam P Butler; Giovanni Cazzaniga; Andrea Biondi; Jan Zuna; Helena Kempski; Markus Muschen; Anthony M Ford; Michael R Stratton; Mel Greaves; Peter J Campbell
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 38.330

4.  Prenatal origin of acute lymphoblastic leukaemia in children.

Authors:  J L Wiemels; G Cazzaniga; M Daniotti; O B Eden; G M Addison; G Masera; V Saha; A Biondi; M F Greaves
Journal:  Lancet       Date:  1999-10-30       Impact factor: 79.321

5.  RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

Authors:  Adam G W Matthews; Alex J Kuo; Santiago Ramón-Maiques; Sunmi Han; Karen S Champagne; Dmitri Ivanov; Mercedes Gallardo; Dylan Carney; Peggie Cheung; David N Ciccone; Kay L Walter; Paul J Utz; Yang Shi; Tatiana G Kutateladze; Wei Yang; Or Gozani; Marjorie A Oettinger
Journal:  Nature       Date:  2007-11-21       Impact factor: 49.962

6.  BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros.

Authors:  Charles G Mullighan; Christopher B Miller; Ina Radtke; Letha A Phillips; James Dalton; Jing Ma; Deborah White; Timothy P Hughes; Michelle M Le Beau; Ching-Hon Pui; Mary V Relling; Sheila A Shurtleff; James R Downing
Journal:  Nature       Date:  2008-04-13       Impact factor: 49.962

7.  Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.

Authors:  Shinobu Tsuzuki; Masao Seto; Mel Greaves; Tariq Enver
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-20       Impact factor: 11.205

8.  Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).

Authors:  Ilaria Iacobucci; Clelia Tiziana Storlazzi; Daniela Cilloni; Annalisa Lonetti; Emanuela Ottaviani; Simona Soverini; Annalisa Astolfi; Sabina Chiaretti; Antonella Vitale; Francesca Messa; Luciana Impera; Carmen Baldazzi; Pietro D'Addabbo; Cristina Papayannidis; Angelo Lonoce; Sabrina Colarossi; Marco Vignetti; Pier Paolo Piccaluga; Stefania Paolini; Domenico Russo; Fabrizio Pane; Giuseppe Saglio; Michele Baccarani; Robin Foà; Giovanni Martinelli
Journal:  Blood       Date:  2009-07-09       Impact factor: 22.113

9.  High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

Authors:  R P Kuiper; E F P M Schoenmakers; S V van Reijmersdal; J Y Hehir-Kwa; A Geurts van Kessel; F N van Leeuwen; P M Hoogerbrugge
Journal:  Leukemia       Date:  2007-04-19       Impact factor: 11.528

10.  V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

Authors:  Rodrig Marculescu; Trang Le; Paul Simon; Ulrich Jaeger; Bertrand Nadel
Journal:  J Exp Med       Date:  2002-01-07       Impact factor: 14.307
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