Literature DB >> 24473320

HOXB13, RFX6 and prostate cancer risk.

Ian G Mills1.   

Abstract

A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

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Year:  2014        PMID： 24473320     DOI： 10.1038/ng.2881

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  7 in total

1.  Principles for the post-GWAS functional characterization of cancer risk loci.

Authors:  Matthew L Freedman; Alvaro N A Monteiro; Simon A Gayther; Gerhard A Coetzee; Angela Risch; Christoph Plass; Graham Casey; Mariella De Biasi; Chris Carlson; David Duggan; Michael James; Pengyuan Liu; Jay W Tichelaar; Haris G Vikis; Ming You; Ian G Mills
Journal:  Nat Genet       Date:  2011-06       Impact factor: 38.330

2.  A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

Authors:  Qilai Huang; Thomas Whitington; Ping Gao; Johan F Lindberg; Yuehong Yang; Jielin Sun; Marja-Riitta Väisänen; Robert Szulkin; Matti Annala; Jian Yan; Lars A Egevad; Kai Zhang; Ruizhu Lin; Arttu Jolma; Matti Nykter; Aki Manninen; Fredrik Wiklund; Markku H Vaarala; Tapio Visakorpi; Jianfeng Xu; Jussi Taipale; Gong-Hong Wei
Journal:  Nat Genet       Date:  2014-01-05       Impact factor: 38.330

3.  A genome-wide survey over the ChIP-on-chip identified androgen receptor-binding genomic regions identifies a novel prostate cancer susceptibility locus at 12q13.13.

Authors:  Junjie Feng; Jielin Sun; Seong-Tae Kim; Yizhen Lu; Zhong Wang; Zheng Zhang; Henrik Gronberg; William B Isaacs; S Lilly Zheng; Jianfeng Xu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-09-29       Impact factor: 4.254

4.  Germline mutations in HOXB13 and prostate-cancer risk.

Authors:  Charles M Ewing; Anna M Ray; Ethan M Lange; Kimberly A Zuhlke; Christiane M Robbins; Waibhav D Tembe; Kathleen E Wiley; Sarah D Isaacs; Dorhyun Johng; Yunfei Wang; Chris Bizon; Guifang Yan; Marta Gielzak; Alan W Partin; Vijayalakshmi Shanmugam; Tyler Izatt; Shripad Sinari; David W Craig; S Lilly Zheng; Patrick C Walsh; James E Montie; Jianfeng Xu; John D Carpten; William B Isaacs; Kathleen A Cooney
Journal:  N Engl J Med       Date:  2012-01-12       Impact factor: 91.245

5.  Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.

Authors:  Yizhen Lu; Zheng Zhang; Hongjie Yu; S Lily Zheng; William B Isaacs; Jianfeng Xu; Jielin Sun
Journal:  Prostate       Date:  2010-12-06       Impact factor: 4.104

6.  The homeodomain protein HOXB13 regulates the cellular response to androgens.

Authors:  John D Norris; Ching-Yi Chang; Bryan M Wittmann; Rebecca S Kunder; Huaxia Cui; Daju Fan; James D Joseph; Donald P McDonnell
Journal:  Mol Cell       Date:  2009-11-13       Impact factor: 17.970

7.  Functional enhancers at the gene-poor 8q24 cancer-linked locus.

Authors:  Li Jia; Gilad Landan; Mark Pomerantz; Rami Jaschek; Paula Herman; David Reich; Chunli Yan; Omar Khalid; Phil Kantoff; William Oh; J Robert Manak; Benjamin P Berman; Brian E Henderson; Baruch Frenkel; Christopher A Haiman; Matthew Freedman; Amos Tanay; Gerhard A Coetzee
Journal:  PLoS Genet       Date:  2009-08-14       Impact factor: 5.917
  7 in total
  3 in total

1.  Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer.

Authors:  Gopalakrishnan Chandrasekaran; Eu Chang Hwang; Taek Won Kang; Dong Deuk Kwon; Kwangsung Park; Je-Jung Lee; Vinoth-Kumar Lakshmanan
Journal:  Sci Rep       Date:  2017-03-08       Impact factor: 4.379

Review 2.  RFX1: a promising therapeutic arsenal against cancer.

Authors:  Joby Issac; Pooja S Raveendran; Ani V Das
Journal:  Cancer Cell Int       Date:  2021-05-08       Impact factor: 5.722

3.  Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error.

Authors:  M Shipitsin; C Small; S Choudhury; E Giladi; S Friedlander; J Nardone; S Hussain; A D Hurley; C Ernst; Y E Huang; H Chang; T P Nifong; D L Rimm; J Dunyak; M Loda; D M Berman; P Blume-Jensen
Journal:  Br J Cancer       Date:  2014-07-17       Impact factor: 7.640
  3 in total

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