Literature DB >> 24472508

Antioxidant and immunoregulatory activity of alkali-extractable polysaccharides from North American ginseng.

Xiaona Yu1, Xiushi Yang2, Bo Cui3, Lijun Wang4, Guixing Ren5.   

Abstract

The alkali-extractable polysaccharide (AEP) was isolated from the root of North American ginseng. Two fractions, AEP-1 and AEP-2, were further purified by gel filtration column chromatography. Gas chromatography analysis identified that AEP-1 was composed of Glc, Gal and GalA. And AEP-2 mainly contained Ara, Man, Gal, Glc and GalA. Antioxidant assays indicated that AEP and AEP-2 exhibited significant antioxidant activities in a dose-dependent manner. AEP-2 also exhibited macrophage-activating activity by increasing NO, TNF-α and IL-6 production. The results suggest that AEP-2 could be used as potential antioxidants and immunomodulators.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alkali-extractable polysaccharide; Bioactivity; North American ginseng

Mesh：

Substances：

Year:  2014        PMID： 24472508     DOI： 10.1016/j.ijbiomac.2014.01.046

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  9 in total

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Journal:  Int J Mol Sci       Date:  2014-10-23       Impact factor: 5.923

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5.  Immunomodulatory activity of glycoproteins isolated from chickpea (Cicer arietinum L.).

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Journal:  Front Nutr       Date:  2022-09-16

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Journal:  Aging Dis       Date:  2017-12-01       Impact factor: 6.745

7.  Proteomics research and related functional classification of liquid sclerotial exudates of Sclerotinia ginseng.

Authors:  Dan Wang; Jun Fan Fu; Ru Jun Zhou; Zi Bo Li; Yu Jiao Xie
Journal:  PeerJ       Date:  2017-10-31       Impact factor: 2.984

8.  Quality evaluation of Panax quinquefolium from different cultivation regions based on their ginsenoside content and radioprotective effects on irradiated mice.

Authors:  Dengqun Liao; Chan Jia; Peng Sun; Jianjun Qi; Xian'en Li
Journal:  Sci Rep       Date:  2019-01-31       Impact factor: 4.379

Review 9.  A review of the immunomodulatory activities of polysaccharides isolated from Panax species.

Authors:  Yeye Hu; Yang He; Zhiqiang Niu; Ting Shen; Ji Zhang; Xinfeng Wang; Weicheng Hu; Jae Youl Cho
Journal:  J Ginseng Res       Date:  2021-06-04       Impact factor: 6.060
  9 in total

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