| Literature DB >> 24472146 |
Singanan Ponnuchamy1, Selvaraj Kanchithalaivan2, Raju Ranjith Kumar3, Mohamed Ashraf Ali4, Tan Soo Choon5.
Abstract
A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM. Compound 1m exhibited maximum potency being 5.87 fold more active at EC50 and 6.26 fold more active at EC90 than the standard drug pyrimethamine.Entities:
Keywords: Antimycobacterial activity; High Throughput Screen; Knoevenagel condensation; Mycobacterium tuberculosis; Thiazolidine-2,4-dione
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Year: 2014 PMID： 24472146 DOI： 10.1016/j.bmcl.2014.01.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823