| Literature DB >> 24470093 |
Daiana Silva Avila1, Robson Luiz Puntel, Michael Aschner.
Abstract
Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.Entities:
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Year: 2013 PMID: 24470093 PMCID: PMC6589086 DOI: 10.1007/978-94-007-7500-8_7
Source DB: PubMed Journal: Met Ions Life Sci ISSN: 1559-0836