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Literature DB >> 24469311

Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.

Bárbara Herranz-Blanco¹, Laura R Arriaga, Ermei Mäkilä, Alexandra Correia, Neha Shrestha, Sabiruddin Mirza, David A Weitz, Jarno Salonen, Jouni Hirvonen, Hélder A Santos.

Abstract

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

Entities: Chemical

Mesh：

Year: 2014 PMID： 24469311 PMCID： PMC4092317 DOI： 10.1039/c3lc51260f

Source DB: PubMed Journal: Lab Chip ISSN： 1473-0189 Impact factor: 6.799

30 in total

1. Intravenous delivery of hydrophobin-functionalized porous silicon nanoparticles: stability, plasma protein adsorption and biodistribution.

Authors: Mirkka Sarparanta; Luis M Bimbo; Jussi Rytkönen; Ermei Mäkilä; Timo J Laaksonen; Päivi Laaksonen; Markus Nyman; Jarno Salonen; Markus B Linder; Jouni Hirvonen; Hélder A Santos; Anu J Airaksinen
Journal: Mol Pharm Date: 2012-02-01 Impact factor: 4.939

2. Tablet preformulations of indomethacin-loaded mesoporous silicon microparticles.

Authors: Maria Tahvanainen; Tanja Rotko; Ermei Mäkilä; Hélder A Santos; Diogo Neves; Timo Laaksonen; Aki Kallonen; Keijo Hämäläinen; Marko Peura; Ritva Serimaa; Jarno Salonen; Jouni Hirvonen; Leena Peltonen
Journal: Int J Pharm Date: 2011-10-28 Impact factor: 5.875

3. Multicompartment polymersomes from double emulsions.

Authors: Ho Cheung Shum; Yuan-jin Zhao; Shin-Hyun Kim; David A Weitz
Journal: Angew Chem Int Ed Engl Date: 2011-01-07 Impact factor: 15.336

4. Double-emulsion drops with ultra-thin shells for capsule templates.

Authors: Shin-Hyun Kim; Jin Woong Kim; Jun-Cheol Cho; David A Weitz
Journal: Lab Chip Date: 2011-08-02 Impact factor: 6.799

5. Encapsulation efficiency of water-soluble and insoluble drugs in liposomes prepared by the microencapsulation vesicle method.

Authors: Tomoko Nii; Fumiyoshi Ishii
Journal: Int J Pharm Date: 2005-07-14 Impact factor: 5.875

6. Comparison of mesoporous silicon and non-ordered mesoporous silica materials as drug carriers for itraconazole.

Authors: Päivi Kinnari; Ermei Mäkilä; Teemu Heikkilä; Jarno Salonen; Jouni Hirvonen; Hélder A Santos
Journal: Int J Pharm Date: 2011-05-12 Impact factor: 5.875

7. New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles.

Authors: Nuno Vale; Ermei Mäkilä; Jarno Salonen; Paula Gomes; Jouni Hirvonen; Hélder A Santos
Journal: Eur J Pharm Biopharm Date: 2012-03-06 Impact factor: 5.571

8. Controlling release from pH-responsive microcapsules.

Authors: Alireza Abbaspourrad; Sujit S Datta; David A Weitz
Journal: Langmuir Date: 2013-10-02 Impact factor: 3.882

9. Polymersomes containing a hydrogel network for high stability and controlled release.

Authors: Shin-Hyun Kim; Jin Woong Kim; Do-Hoon Kim; Sang-Hoon Han; David A Weitz
Journal: Small Date: 2012-09-07 Impact factor: 13.281

10. Co-delivery of a hydrophobic small molecule and a hydrophilic peptide by porous silicon nanoparticles.

Authors: Dongfei Liu; Luis M Bimbo; Ermei Mäkilä; Francesca Villanova; Martti Kaasalainen; Barbara Herranz-Blanco; Carla M Caramella; Vesa-Pekka Lehto; Jarno Salonen; Karl-Heinz Herzig; Jouni Hirvonen; Hélder A Santos
Journal: J Control Release Date: 2013-06-10 Impact factor: 9.776

12 in total

1. Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression.

Authors: Hongbo Zhang; Wenguo Cui; Xiangmeng Qu; Huayin Wu; Liangliang Qu; Xu Zhang; Ermei Mäkilä; Jarno Salonen; Yueqi Zhu; Zhou Yang; Dong Chen; Hélder A Santos; Mingtan Hai; David A Weitz
Journal: Proc Natl Acad Sci U S A Date: 2019-03-29 Impact factor: 11.205

2. Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites.

Authors: Myat Noe Hsu; Rongcong Luo; Kerwin Zeming Kwek; Yong Chen Por; Yong Zhang; Chia-Hung Chen
Journal: Biomicrofluidics Date: 2015-03-24 Impact factor: 2.800

3. Microencapsulation of indocyanine green for potential applications in image-guided drug delivery.

Authors: Zhiqiang Zhu; Ting Si; Ronald X Xu
Journal: Lab Chip Date: 2015-02-07 Impact factor: 6.799

4. A Microfluidic Platform to design crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for enhanced MRI.

Authors: Maria Russo; Paolo Bevilacqua; Paolo Antonio Netti; Enza Torino
Journal: Sci Rep Date: 2016-11-30 Impact factor: 4.379

Review 5. Microfluidic Devices for Drug Delivery Systems and Drug Screening.

Authors: Samar Damiati; Uday B Kompella; Safa A Damiati; Rimantas Kodzius
Journal: Genes (Basel) Date: 2018-02-16 Impact factor: 4.096

6. High-Throughput Production of Micrometer Sized Double Emulsions and Microgel Capsules in Parallelized 3D Printed Microfluidic Devices.

Authors: Alexander Jans; Jonas Lölsberg; Abdolrahman Omidinia-Anarkoli; Robin Viermann; Martin Möller; Laura De Laporte; Matthias Wessling; Alexander J C Kuehne
Journal: Polymers (Basel) Date: 2019-11-15 Impact factor: 4.329

10. Enhancement of Peroxidase Stability Against Oxidative Self-Inactivation by Co-immobilization with a Redox-Active Protein in Mesoporous Silicon and Silica Microparticles.

Authors: P Sahare; M Ayala; R Vazquez-Duhalt; U Pal; A Loni; L T Canham; I Osorio; V Agarwal
Journal: Nanoscale Res Lett Date: 2016-09-20 Impact factor: 4.703