| Literature DB >> 2446889 |
C A Maggi1, P Santicioli, R Patacchini, D Turini, G Barbanti, P Beneforti, S Giuliani, A Meli.
Abstract
Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.Entities:
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Year: 1987 PMID: 2446889 DOI: 10.1016/0014-2999(87)90744-8
Source DB: PubMed Journal: Eur J Pharmacol ISSN: 0014-2999 Impact factor: 4.432