Arvind K Pandey1, Michael J Blaha2, Kavita Sharma2, Juan Rivera2, Matthew J Budoff3, Ron Blankstein4, Mouaz Al-Mallah5, Nathan D Wong6, Leslee Shaw7, Jeffery Carr8, Daniel O'Leary9, Joao A C Lima2, Moyses Szklo10, Roger S Blumenthal2, Khurram Nasir11. 1. Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA. 2. Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA. 3. Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, USA. 4. Non-invasive Cardiovascular Imaging Program, Brigham and Women's Hospital, Boston, MA, USA. 5. Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA. 6. Division of Cardiology, University of California, Irvine, CA, USA. 7. Division of Cardiology, Emory University, Atlanta, GA, USA. 8. Department of Radiology, Wake Forest University Health Sciences, Winston-Salem, NC, USA. 9. St. Elizabeth's Medical Center, Boston, MA, USA. 10. Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA. 11. Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA; Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami Beach, FL, USA; Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA; Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA. Electronic address: KhurramN@baptisthealth.net.
Abstract
OBJECTIVE: We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND: MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. METHODS: A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1 ± 1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. RESULTS: A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p < 0.01) for incident development of CAC after adjusting for risk factors and demographics. A premature family history was associated with 14.4 units (p < 0.01) greater volume scores compared to those with no family history in similarly adjusted models by median regression analysis. A combined parental and sibling family history was associated with the greatest incidence and progression in demographic-adjusted models. Caucasians demonstrated the most consistent predictive relationship between family history of premature CHD and incidence (p < 0.01) and progression (p < 0.05) of CAC, though no significant interaction with ethnicity was noted. CONCLUSIONS: Family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors, in a multiethnic, population-based study.
OBJECTIVE: We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND:MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. METHODS: A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1 ± 1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. RESULTS: A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p < 0.01) for incident development of CAC after adjusting for risk factors and demographics. A premature family history was associated with 14.4 units (p < 0.01) greater volume scores compared to those with no family history in similarly adjusted models by median regression analysis. A combined parental and sibling family history was associated with the greatest incidence and progression in demographic-adjusted models. Caucasians demonstrated the most consistent predictive relationship between family history of premature CHD and incidence (p < 0.01) and progression (p < 0.05) of CAC, though no significant interaction with ethnicity was noted. CONCLUSIONS: Family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors, in a multiethnic, population-based study.
Authors: Samuel S Gidding; C Alex McMahan; Henry C McGill; Laura A Colangelo; Pamela J Schreiner; O Dale Williams; Kiang Liu Journal: Arch Intern Med Date: 2006-11-27
Authors: Philip Greenland; Robert O Bonow; Bruce H Brundage; Matthew J Budoff; Mark J Eisenberg; Scott M Grundy; Michael S Lauer; Wendy S Post; Paolo Raggi; Rita F Redberg; George P Rodgers; Leslee J Shaw; Allen J Taylor; William S Weintraub; Robert A Harrington; Jonathan Abrams; Jeffrey L Anderson; Eric R Bates; Cindy L Grines; Mark A Hlatky; Robert C Lichtenberg; Jonathan R Lindner; Gerald M Pohost; Richard S Schofield; Samuel J Shubrooks; James H Stein; Cynthia M Tracy; Robert A Vogel; Deborah J Wesley Journal: Circulation Date: 2007-01-12 Impact factor: 29.690
Authors: Yadon Arad; Louise A Spadaro; Marguerite Roth; David Newstein; Alan D Guerci Journal: J Am Coll Cardiol Date: 2005-07-05 Impact factor: 24.094
Authors: Robert C Detrano; Melissa Anderson; Jennifer Nelson; Nathan D Wong; J Jeffrey Carr; Michael McNitt-Gray; Diane E Bild Journal: Radiology Date: 2005-06-21 Impact factor: 11.105
Authors: Adam Kretowski; Kim McFann; John E Hokanson; David Maahs; Gregory Kinney; Janet K Snell-Bergeon; R Paul Wadwa; Robert H Eckel; Lorraine Ogden; Satish Garg; Jia Li; Suzanne Cheng; Henry A Erlich; Marian Rewers Journal: Diabetes Date: 2007-03 Impact factor: 9.461
Authors: Steven E Nissen; Stephen J Nicholls; Ilke Sipahi; Peter Libby; Joel S Raichlen; Christie M Ballantyne; Jean Davignon; Raimund Erbel; Jean Charles Fruchart; Jean-Claude Tardif; Paul Schoenhagen; Tim Crowe; Valerie Cain; Kathy Wolski; Marlene Goormastic; E Murat Tuzcu Journal: JAMA Date: 2006-03-13 Impact factor: 56.272
Authors: Khurram Nasir; Matthew J Budoff; Nathan D Wong; Maren Scheuner; David Herrington; Donna K Arnett; Moyses Szklo; Philip Greenland; Roger S Blumenthal Journal: Circulation Date: 2007-07-23 Impact factor: 29.690
Authors: Richard A Kronmal; Robyn L McClelland; Robert Detrano; Steven Shea; João A Lima; Mary Cushman; Diane E Bild; Gregory L Burke Journal: Circulation Date: 2007-05-14 Impact factor: 29.690
Authors: Randy Cohen; Matthew Budoff; Robyn L McClelland; Stefan Sillau; Gregory Burke; Michael Blaha; Moyses Szklo; Seth Uretsky; Alan Rozanski; Steven Shea Journal: Am J Cardiol Date: 2014-07-30 Impact factor: 2.778
Authors: Jane J Lee; Alison Pedley; Udo Hoffmann; Joseph M Massaro; Christopher J O'Donnell; Emelia J Benjamin; Michelle T Long Journal: Am J Cardiol Date: 2017-10-19 Impact factor: 2.778
Authors: Dan K Kalra; Ran Heo; Valentina Valenti; Ryo Nakazato; James K Min Journal: Arterioscler Thromb Vasc Biol Date: 2014-04-10 Impact factor: 8.311
Authors: Matthew J Budoff; Paolo Raggi; George A Beller; Daniel S Berman; Regina S Druz; Shaista Malik; Vera H Rigolin; Wm Guy Weigold; Prem Soman Journal: JACC Cardiovasc Imaging Date: 2016-02
Authors: Hanxiang Gao; Lin Li; Shaoqi Rao; Gongqing Shen; Quansheng Xi; Shenghan Chen; Zheng Zhang; Kai Wang; Stephen G Ellis; Qiuyun Chen; Eric J Topol; Qing K Wang Journal: PLoS One Date: 2014-12-08 Impact factor: 3.240