Felix Darstein1, Christina König1, Maria Hoppe-Lotichius2, Daniel Grimm1, Johanna Knapstein1, Jens Mittler2, Hauke Lang2, Peter Robert Galle1, Tim Zimmermann3. 1. I. Medizinische Klinik der Universitätsmedizin Mainz, Universitätsmedizin Mainz, Langenbeckstraße 1, 55131 Mainz, Germany. 2. Viszeral- und Transplantationschirurgie der Universitätsmedizin Mainz, Universitätsmedizin Mainz, Langenbeckstraße 1, 55131 Mainz, Germany. 3. I. Medizinische Klinik der Universitätsmedizin Mainz, Universitätsmedizin Mainz, Langenbeckstraße 1, 55131 Mainz, Germany. Electronic address: tim.zimmermann@unimedizin-mainz.de.
Abstract
BACKGROUND: Diseases leading to end-stage liver disease (ESLD), especially alcoholic liver cirrhosis cause comorbidities of the pancreas, too. The aim of this retrospective study was to determine the impact of pancreatic alterations diagnosed pretransplant on the outcome after liver transplantation (LT). METHODS: In total, data from 372 LT patients were analyzed. Patients were followed up for a mean of 4.2 years. Incidence of chronic pancreatitis (CP), pancreatic cysts (PC) and intraductal papillary mucinous neoplasm (IPMN) was acquired retrospectively from patient's charts. RESULTS: CP, IPMN and PC were rarely diagnosed in LT-recipients [CP (3.8%), PC (1.6%) and IPMN (1.6%)]. There was no significant correlation of IPMN, CP, PC and other patient characteristics. The prevalence of CP (log rank: p=0.315), PC (log rank: p=0.242) and IPMN (log rank: p=0.491) did not influence patient survival. CONCLUSION: Frequency of radiological alterations of the pancreas in LT recipients (such as CP, PC, IPMN) diagnosed by sonography, CT scan or MRI is comparable to the non-transplant population. Short term survival of LT-recipients after transplantation is not reduced for patients with CP, PC and patients with branch-duct IPMN (with a low-risk for malignancy according to international consensus guidelines).
BACKGROUND: Diseases leading to end-stage liver disease (ESLD), especially alcoholic liver cirrhosis cause comorbidities of the pancreas, too. The aim of this retrospective study was to determine the impact of pancreatic alterations diagnosed pretransplant on the outcome after liver transplantation (LT). METHODS: In total, data from 372 LT patients were analyzed. Patients were followed up for a mean of 4.2 years. Incidence of chronic pancreatitis (CP), pancreatic cysts (PC) and intraductal papillary mucinous neoplasm (IPMN) was acquired retrospectively from patient's charts. RESULTS: CP, IPMN and PC were rarely diagnosed in LT-recipients [CP (3.8%), PC (1.6%) and IPMN (1.6%)]. There was no significant correlation of IPMN, CP, PC and other patient characteristics. The prevalence of CP (log rank: p=0.315), PC (log rank: p=0.242) and IPMN (log rank: p=0.491) did not influence patient survival. CONCLUSION: Frequency of radiological alterations of the pancreas in LT recipients (such as CP, PC, IPMN) diagnosed by sonography, CT scan or MRI is comparable to the non-transplant population. Short term survival of LT-recipients after transplantation is not reduced for patients with CP, PC and patients with branch-duct IPMN (with a low-risk for malignancy according to international consensus guidelines).
Authors: Giulia Zerboni; Gabriele Capurso; Marco Di Pietropaolo; Francesco Carbonetti; Elsa Iannicelli; Massimo Marignani; Gianfranco Delle Fave Journal: United European Gastroenterol J Date: 2017-02-09 Impact factor: 4.623