Takaaki Wakamori1, Takashi Agari2, Takao Yasuhara1, Masahiro Kameda1, Akihiko Kondo1, Aiko Shinko1, Susumu Sasada1, Tatsuya Sasaki1, Tomohisa Furuta3, Isao Date1. 1. Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. 2. Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. Electronic address: agarit@cc.okayama-u.ac.jp. 3. Department of Psychology, Kibi International University, Japan.
Abstract
OBJECTIVE: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). METHODS: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. RESULTS: The mean MMSE score of PD patients was 27.4 ± 2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4 ± 17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. CONCLUSIONS: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.
OBJECTIVE: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). METHODS: Eighty-one consecutive PDpatients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. RESULTS: The mean MMSE score of PDpatients was 27.4 ± 2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PDpatients was 88.4 ± 17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PDPatients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PDpatients were positively correlated with rCBF in the thalamus and cingulate gyrus. CONCLUSIONS: This is the study to demonstrate the cognitive impairments in PDpatients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PDpatients was correlated with disease severity and hallucinatory episodes.
Authors: Saranya Sundaram; Rachel L Hughes; Eric Peterson; Eva M Müller-Oehring; Helen M Brontë-Stewart; Kathleen L Poston; Afik Faerman; Chloe Bhowmick; Tilman Schulte Journal: Neurosci Biobehav Rev Date: 2019-05-24 Impact factor: 8.989
Authors: Xueling Suo; Du Lei; Lan Cheng; Nannan Li; Panli Zuo; Danny J J Wang; Xiaoqi Huang; Su Lui; Graham J Kemp; Rong Peng; Qiyong Gong Journal: Hum Brain Mapp Date: 2018-12-07 Impact factor: 5.038
Authors: Colleen P E Rollins; Jane R Garrison; Jon S Simons; James B Rowe; Claire O'Callaghan; Graham K Murray; John Suckling Journal: EClinicalMedicine Date: 2019-02-21