Direct access to α-trifluoromethyl enones via efficient copper-catalyzed trifluoromethylation of Meyer-Schuster rearrangement.

A novel domino copper-catalyzed trifluoromethylated Meyer-Schuster rearrangement reaction with Togni's reagent was developed, leading to α-trifluormethyl (CF3) enone products with moderate to good yields. Furthermore, α-CF3 enones can be transformed toward important trifluoromethyl heterocyclic motifs in a one-pot version.