Literature DB >> 24466406

Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors.

Eugenia Cifuentes-Pagano1, Jaideep Saha2, Gábor Csányi1, Imad Al Ghouleh1, Sanghamitra Sahoo1, Andrés Rodríguez1, Peter Wipf3, Patrick J Pagano4, Erin M Skoda5.   

Abstract

(1SR,4RS)-3,3-Dimethyl-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalenes were synthesized in 2-3 steps from commercially available materials and assessed for specificity and effectiveness across a range of Nox isoforms. The N-pentyl and N-methylenethiophene substituted analogs 11g and 11h emerged as selective Nox2 inhibitors with cellular IC50 values of 20 and 32 μM, respectively.

Entities:  

Year:  2013        PMID： 24466406      PMCID： PMC3897123          DOI： 10.1039/C3MD00061C

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  55 in total

1.  Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans.

Authors:  Stavros P Loukogeorgakis; Merlijn J van den Berg; Reecha Sofat; Dorothea Nitsch; Marietta Charakida; Bu'Hussein Haiyee; Eric de Groot; Raymond J MacAllister; Taco W Kuijpers; John E Deanfield
Journal:  Circulation       Date:  2010-05-17       Impact factor: 29.690

2.  Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

Authors:  Gábor Csányi; Eugenia Cifuentes-Pagano; Imad Al Ghouleh; Daniel J Ranayhossaini; Loreto Egaña; Lucia R Lopes; Heather M Jackson; Eric E Kelley; Patrick J Pagano
Journal:  Free Radic Biol Med       Date:  2011-04-17       Impact factor: 7.376

3.  Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery.

Authors:  Gary M Jacobson; Hector M Dourron; Jianhua Liu; Oscar A Carretero; Daniel J Reddy; Tanja Andrzejewski; Patrick J Pagano
Journal:  Circ Res       Date:  2003-02-27       Impact factor: 17.367

4.  Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Authors:  Antonio Valencia; Ellen Sapp; Jeffrey S Kimm; Hollis McClory; Patrick B Reeves; Jonathan Alexander; Kwadwo A Ansong; Nicholas Masso; Matthew P Frosch; Kimberly B Kegel; Xueyi Li; Marian DiFiglia
Journal:  Hum Mol Genet       Date:  2012-12-07       Impact factor: 6.150

5.  Comparative pharmacology of chemically distinct NADPH oxidase inhibitors.

Authors:  S Wind; K Beuerlein; T Eucker; H Müller; P Scheurer; M E Armitage; H Ho; H H H W Schmidt; K Wingler
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

6.  NOX and inflammation in the vascular adventitia.

Authors:  Gábor Csányi; W Robert Taylor; Patrick J Pagano
Journal:  Free Radic Biol Med       Date:  2009-07-21       Impact factor: 7.376

Review 7.  Nox proteins in signal transduction.

Authors:  David I Brown; Kathy K Griendling
Journal:  Free Radic Biol Med       Date:  2009-07-21       Impact factor: 7.376

Review 8.  Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets.

Authors:  Vincent Jaquet; Leonardo Scapozza; Robert A Clark; Karl-Heinz Krause; J David Lambeth
Journal:  Antioxid Redox Signal       Date:  2009-10       Impact factor: 8.401

Review 9.  Activation and assembly of the NADPH oxidase: a structural perspective.

Authors:  Yvonne Groemping; Katrin Rittinger
Journal:  Biochem J       Date:  2005-03-15       Impact factor: 3.857

10.  Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain.

Authors:  Yukio Nisimoto; Heather M Jackson; Hisamitsu Ogawa; Tsukasa Kawahara; J David Lambeth
Journal:  Biochemistry       Date:  2010-03-23       Impact factor: 3.162
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  13 in total

1.  High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

Authors:  Jacek Zielonka; Gang Cheng; Monika Zielonka; Thota Ganesh; Aiming Sun; Joy Joseph; Radosław Michalski; William J O'Brien; J David Lambeth; Balaraman Kalyanaraman
Journal:  J Biol Chem       Date:  2014-04-24       Impact factor: 5.157

2.  High-Throughput Screening of NOX Inhibitors.

Authors:  Jacek Zielonka; Monika Zielonka; Gang Cheng; Micael Hardy; Balaraman Kalyanaraman
Journal:  Methods Mol Biol       Date:  2019

3.  Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases.

Authors:  Jacek Zielonka; Micael Hardy; Radosław Michalski; Adam Sikora; Monika Zielonka; Gang Cheng; Olivier Ouari; Radosław Podsiadły; Balaraman Kalyanaraman
Journal:  Cell Biochem Biophys       Date:  2017-06-29       Impact factor: 2.194

Review 4.  Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors.

Authors:  M Eugenia Cifuentes-Pagano; Daniel N Meijles; Patrick J Pagano
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

Review 5.  Microvascular NADPH oxidase in health and disease.

Authors:  Yao Li; Patrick J Pagano
Journal:  Free Radic Biol Med       Date:  2017-03-06       Impact factor: 7.376

Review 6.  The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls.

Authors:  Eugenia Cifuentes-Pagano; Daniel N Meijles; Patrick J Pagano
Journal:  Antioxid Redox Signal       Date:  2013-12-14       Impact factor: 8.401

7.  Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway.

Authors:  Chong Xu; Xiaoxue Wang; Chenjian Gu; Hai Zhang; Ruijie Zhang; Xiaoqing Dong; Chunxiao Liu; Xiaoyu Hu; Xiang Ji; Shile Huang; Long Chen
Journal:  J Neurochem       Date:  2017-02-24       Impact factor: 5.372

Review 8.  The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology.

Authors:  Evan DeVallance; Yao Li; Michael J Jurczak; Eugenia Cifuentes-Pagano; Patrick J Pagano
Journal:  Antioxid Redox Signal       Date:  2019-10-01       Impact factor: 8.401

9.  NADPH oxidase 2 activity in Parkinson's disease.

Authors:  Matthew T Keeney; Eric K Hoffman; Kyle Farmer; Christopher R Bodle; Marco Fazzari; Alevtina Zharikov; Sandra L Castro; Xiaoping Hu; Amanda Mortimer; Julia K Kofler; Eugenia Cifuentes-Pagano; Patrick J Pagano; Edward A Burton; Teresa G Hastings; J Timothy Greenamyre; Roberto Di Maio
Journal:  Neurobiol Dis       Date:  2022-05-13       Impact factor: 7.046

Review 10.  NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

Authors:  Sanghamitra Sahoo; Daniel N Meijles; Patrick J Pagano
Journal:  Clin Sci (Lond)       Date:  2016-03       Impact factor: 6.124
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