Literature DB >> 2446625

Effect of PGI2 on transcellular transport of fluorescein dextran through an arterial endothelial monolayer.

Y Mizuno-Yagyu1, R Hashida, C Mineo, S Ikegami, S Ohkuma, T Takano.   

Abstract

The effects of prostacyclin (PGI2) and stable derivatives of PGI2, such as isocarbacyclin (PGI2 deriv. (A] and isocarbacyclin methyl ester (PGI2 deriv. (B)), on junctional transport of fluorescein dextran (FD) through cultured porcine arterial endothelial cells were investigated. These PGI2S inhibited the transcellular transport dose-dependently. After the elimination of PGI2, its inhibitory effect persisted for at least 1 hr. A good correlation was found between increase of cAMP and the potency of inhibition. Increase of cAMP after PGI2 treatment seemed to be involved in the inhibition of FD transport.

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Year:  1987        PMID： 2446625     DOI： 10.1016/0006-2952(87)90442-4

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  10 in total

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Authors:  A Baranczyk-Kuzma; K L Audus; F L Guillot; R T Borchardt
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2.  Effects of isocarbacyclin, a stable prostacyclin analogue, on monkey isolated cerebral and peripheral arteries.

Authors:  Y Kawai; T Ohhashi
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739

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  10 in total

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