| Literature DB >> 24463256 |
Nancy Blüthgen1, Nicole Meili2, Geraldine Chew2, Alex Odermatt3, Karl Fent4.
Abstract
Wide application of the UV-filter octocrylene (OC) in cosmetics leads to contamination of the aquatic environment, but effects of OC remain unclear. Here we determine bioaccumulation and molecular effects of OC. Adult male zebrafish were exposed to 22, 209 and 383 μg/L and embryos to 69, 293 and 925 μg/L OC. OC accumulated in fish up to 17 μg/g. Calculated BCF varied between 41 and 136. Microarray analysis in brain and liver following exposure to 383 μg/L OC revealed alteration of 628 and 136 transcripts, respectively. Most prominent GO processes included developmental processes, organ development, hematopoiesis, formation of blood vessels, blood circulation, fat cell differentiation and metabolism. Validation by RT-qPCR in brain and liver of adult fish and embryos included a series of genes. Blood levels of 11-ketotestosterone were not altered. The transcriptomics data suggest that OC mainly affects transcription of genes related to developmental processes in the brain and liver as well as metabolic processes in the liver.Entities:
Keywords: Bioaccumulation; Microarray; Octocrylene; Personal care products; Transcriptomics; UV-filter
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Year: 2014 PMID： 24463256 DOI： 10.1016/j.scitotenv.2014.01.015
Source DB: PubMed Journal: Sci Total Environ ISSN： 0048-9697 Impact factor: 7.963