Literature DB >> 24462695

Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease.

Young-Man Kwon1, Hye Suk Hwang1, Jong Seok Lee1, Eun-Ju Ko1, Si-Eun Yoo1, Min-Chul Kim2, Yu-Na Lee1, Ki-Hye Kim1, Jae-Min Song3, Sujin Lee4, Martin L Moore4, Sang-Moo Kang5.   

Abstract

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  FI-RSV; Maternal antibodies; Passive immunization; Vaccine enhanced disease

Mesh:

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Year:  2014        PMID: 24462695      PMCID: PMC3960005          DOI: 10.1016/j.antiviral.2014.01.008

Source DB:  PubMed          Journal:  Antiviral Res        ISSN: 0166-3542            Impact factor:   5.970


  30 in total

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