| Literature DB >> 24462695 |
Young-Man Kwon1, Hye Suk Hwang1, Jong Seok Lee1, Eun-Ju Ko1, Si-Eun Yoo1, Min-Chul Kim2, Yu-Na Lee1, Ki-Hye Kim1, Jae-Min Song3, Sujin Lee4, Martin L Moore4, Sang-Moo Kang5.
Abstract
Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.Entities:
Keywords: FI-RSV; Maternal antibodies; Passive immunization; Vaccine enhanced disease
Mesh:
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Year: 2014 PMID: 24462695 PMCID: PMC3960005 DOI: 10.1016/j.antiviral.2014.01.008
Source DB: PubMed Journal: Antiviral Res ISSN: 0166-3542 Impact factor: 5.970