Amanda Galvão-de Almeida1, Lucas C Quarantini2, Amanda Guindalini Tartaglioni3, André C Lyra4, Carmen Lívia Parise5, Raymundo Paraná4, Irismar R de Oliveira6, Angela Miranda-Scippa7, Camila Guindalini8. 1. Department of Neurosciences and Mental Health, Medical School, Universidade Federal da Bahia, Bahia, Brazil; Department of Psychiatry and Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Medical School, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address: acgalvao@ufba.br. 2. Department of Neurosciences and Mental Health, Medical School, Universidade Federal da Bahia, Bahia, Brazil; Psychiatry Service, University Hospital, Universidade Federal da Bahia, Bahia, Brazil. 3. Department of Psychobiology, Medical School, Universidade Federal de São Paulo, São Paulo, Brazil. 4. Department of Gastroenterology, Medical School, Universidade Federal da Bahia, Bahia, Brazil. 5. Hepatitis Unit and Hospital São Paulo, Medical School, Universidade Federal de São Paulo, São Paulo, Brazil. 6. Department of Neurosciences and Mental Health, Medical School, Universidade Federal da Bahia, Bahia, Brazil. 7. Department of Neurosciences and Mental Health, Medical School, Universidade Federal da Bahia, Bahia, Brazil; Department of Psychiatry and Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Medical School, Universidade Federal de São Paulo, São Paulo, Brazil. 8. Psychiatry Service, University Hospital, Universidade Federal da Bahia, Bahia, Brazil; Department of Psychobiology, Medical School, Universidade Federal de São Paulo, São Paulo, Brazil.
Abstract
OBJECTIVE: The aim of this study is to investigate the development of depression during interferon-alpha (IFN-α) therapy and the variations in the expression of the serotonin receptor (5-HTR) and transporter (5-HTT) in hepatitis C patients. METHOD: Hepatitis C patients (n=277) were given the Mini International Neuropsychiatric Interview at the end of IFN-α therapy. Three polymorphisms were genotyped: the serotonin transporter repeat length polymorphic region [5-HTT gene-linked polymorphic region (5-HTTLPR)], as well as SNPs rs25531 and rs6295, located within the 5-HTTLPR and the transcriptional control region of the 5-HTR1A gene, respectively. RESULTS: The diagnosis of current depression, which was associated with IFN-α-related depression (P<.001), demonstrated a statistically significant association with the CC genotype of the 5-HTR1A gene (odds ratio=5.57, 95% confidence interval=1.61-19.24, P=.007). CONCLUSIONS: Persistent depression may represent a more specific type of IFN-α-related psychopathology. Future studies need to investigate the genetic risk factors for vulnerability associated with persistent depression. Limitations, such as the study's cross-sectional design, small sample size and retrospective assessment of IFN-α-induced depression diagnosis, must be taken into account while interpreting the results found in this study.
OBJECTIVE: The aim of this study is to investigate the development of depression during interferon-alpha (IFN-α) therapy and the variations in the expression of the serotonin receptor (5-HTR) and transporter (5-HTT) in hepatitis C patients. METHOD: Hepatitis C patients (n=277) were given the Mini International Neuropsychiatric Interview at the end of IFN-α therapy. Three polymorphisms were genotyped: the serotonin transporter repeat length polymorphic region [5-HTT gene-linked polymorphic region (5-HTTLPR)], as well as SNPs rs25531 and rs6295, located within the 5-HTTLPR and the transcriptional control region of the 5-HTR1A gene, respectively. RESULTS: The diagnosis of current depression, which was associated with IFN-α-related depression (P<.001), demonstrated a statistically significant association with the CC genotype of the 5-HTR1A gene (odds ratio=5.57, 95% confidence interval=1.61-19.24, P=.007). CONCLUSIONS: Persistent depression may represent a more specific type of IFN-α-related psychopathology. Future studies need to investigate the genetic risk factors for vulnerability associated with persistent depression. Limitations, such as the study's cross-sectional design, small sample size and retrospective assessment of IFN-α-induced depression diagnosis, must be taken into account while interpreting the results found in this study.
Authors: Nis P Suppli; Jens D Bukh; Terrie E Moffitt; Avshalom Caspi; Christoffer Johansen; Anne Tjønneland; Lars V Kessing; Susanne O Dalton Journal: Depress Anxiety Date: 2017-06-07 Impact factor: 6.505
Authors: Ricardo Henrique-Araújo; Lucas C Quarantini; André C Caribé; Felipe C Argolo; Ana Paula Jesus-Nunes; Mychelle Morais-de-Jesus; Adriana Dantas-Duarte; Tayne Miranda Moreira; Irismar Reis de Oliveira Journal: Braz J Infect Dis Date: 2019-07-22 Impact factor: 3.257