OBJECTIVE: Several alterations of magnesium metabolism have been associated with type 2 diabetes pathophysiology, a condition particularly frequent in older persons. We aimed to evaluate serum total (Mg-tot) and serum ionized magnesium (Mg-ion) in older persons with type 2 diabetes in order to explore clinically applicable methods for the detection of magnesium deficit. MATERIAL/ METHODS: Mg-tot and Mg-ion were measured in 105 fasting subjects with type 2 diabetes (mean age: 71.1±0.8 years; M/F: 45/60) and in 100 age-matched non-diabetic control persons (mean age: 72.2±0.8 years; M/F: 42/58). RESULTS: Mg-ion concentrations were significantly lower in diabetic persons compared with controls (0.49±0.05 mmol/L vs. 0.55±0.05 mmol/L; p<0.001). Mg-tot was also slightly but significantly lower in diabetic patients (0.82±0.007 mmol/L vs. 0.84±0.006 mmol/L; p<0.05). There was an almost complete overlap in the values of Mg-tot in older diabetic patients and controls; conversely, 44.8% of diabetic patients had Mg-ion values below 0.47 mmol/L, while none of the controls did. After adjustment for age, sex, BMI, and triglycerides, Mg-tot was significantly associated with FBG in all the participants (p<0.05) and Mg-ion was significantly associated with FBG in all the participants (p<0.01) and with HbA1c in diabetic participants (p<0.001). CONCLUSIONS: Alterations of magnesium serum concentrations are common in type 2 diabetic older adults; Mg-ion evaluation may help to identify subclinical magnesium depletion (i.e. in patients with normal Mg-tot); the close independent associations of Mg-tot and Mg-ion with FBG and with HbA1c reinforce the possible link between magnesium homeostasis and altered glucose metabolism.
OBJECTIVE: Several alterations of magnesium metabolism have been associated with type 2 diabetes pathophysiology, a condition particularly frequent in older persons. We aimed to evaluate serum total (Mg-tot) and serum ionizedmagnesium (Mg-ion) in older persons with type 2 diabetes in order to explore clinically applicable methods for the detection of magnesium deficit. MATERIAL/ METHODS:Mg-tot and Mg-ion were measured in 105 fasting subjects with type 2 diabetes (mean age: 71.1±0.8 years; M/F: 45/60) and in 100 age-matched non-diabetic control persons (mean age: 72.2±0.8 years; M/F: 42/58). RESULTS:Mg-ion concentrations were significantly lower in diabeticpersons compared with controls (0.49±0.05 mmol/L vs. 0.55±0.05 mmol/L; p<0.001). Mg-tot was also slightly but significantly lower in diabeticpatients (0.82±0.007 mmol/L vs. 0.84±0.006 mmol/L; p<0.05). There was an almost complete overlap in the values of Mg-tot in older diabeticpatients and controls; conversely, 44.8% of diabeticpatients had Mg-ion values below 0.47 mmol/L, while none of the controls did. After adjustment for age, sex, BMI, and triglycerides, Mg-tot was significantly associated with FBG in all the participants (p<0.05) and Mg-ion was significantly associated with FBG in all the participants (p<0.01) and with HbA1c in diabeticparticipants (p<0.001). CONCLUSIONS: Alterations of magnesium serum concentrations are common in type 2 diabetic older adults; Mg-ion evaluation may help to identify subclinical magnesium depletion (i.e. in patients with normal Mg-tot); the close independent associations of Mg-tot and Mg-ion with FBG and with HbA1c reinforce the possible link between magnesium homeostasis and altered glucose metabolism.
Authors: Christina M Gant; Sabita S Soedamah-Muthu; S Heleen Binnenmars; Stephan J L Bakker; Gerjan Navis; Gozewijn D Laverman Journal: Nutrients Date: 2018-03-05 Impact factor: 5.717
Authors: Jorge Simón; Naroa Goikoetxea-Usandizaga; Marina Serrano-Maciá; David Fernández-Ramos; Diego Sáenz de Urturi; Jessica J Gruskos; Pablo Fernández-Tussy; Sofía Lachiondo-Ortega; Irene González-Recio; Rubén Rodríguez-Agudo; Virginia Gutiérrez-de-Juan; Begoña Rodríguez-Iruretagoyena; Marta Varela-Rey; Paula Gimenez-Mascarell; María Mercado-Gomez; Beatriz Gómez-Santos; Carmen Fernandez-Rodriguez; Fernando Lopitz-Otsoa; Maider Bizkarguenaga; Sibylle Dames; Ute Schaeper; Franz Martin; Guadalupe Sabio; Paula Iruzubieta; Javier Crespo; Patricia Aspichueta; Kevan H-Y Chu; Daniela Buccella; César Martín; Teresa Cardoso Delgado; Luis Alfonso Martínez-Cruz; María Luz Martínez-Chantar Journal: J Hepatol Date: 2021-02-09 Impact factor: 25.083