Hsiu-Li Lin1, Herng-Ching Lin2, Yi-Hua Chen3. 1. Department of Neurology, General Cathay Hospital, Sijhih Branch, New Taipei City, Taiwan. 2. School of Health Care Administration, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. 3. School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. Electronic address: yichen@tmu.edu.tw.
Abstract
PURPOSE: The influence of mental illness early in life on the subsequent risk of Parkinson disease (PD) and its clinical picture remain obscure. This study investigated the effects of psychiatric diseases on a subsequent PD diagnosis. METHODS: We used the Longitudinal Health Insurance Database 2000 of Taiwan to identify 73,597 patients who visited ambulatory care centers or were hospitalized with a first-time diagnosis of anxiety, affective disorders, or schizophrenia between 2001 and 2003 as the study cohort. We also randomly selected 220,791 enrollees matched with the study cohort for comparison. Each patient was individually tracked for 6 years to identify a subsequent PD diagnosis. Stratified Cox proportional hazard regressions were performed for the analysis. RESULTS: The incidence rate of PD per 1000 person-years was 4.91 (95% confidence interval [CI], 4.71-5.12) and 1.63 (95% CI, 1.56-1.70) for the psychiatric and comparison groups, respectively. Patients with psychiatric illnesses were more vulnerable to developing PD than nonpsychiatric individuals, exhibiting a 2.38-fold increased risk (95% CI, 2.23-2.53) after other covariates were considered. Furthermore, patients with schizophrenia exhibited the highest risk for developing PD. CONCLUSIONS: We suggest effective monitoring of patients with psychiatric disturbances for potential long-term neurodegenerative diseases.
PURPOSE: The influence of mental illness early in life on the subsequent risk of Parkinson disease (PD) and its clinical picture remain obscure. This study investigated the effects of psychiatric diseases on a subsequent PD diagnosis. METHODS: We used the Longitudinal Health Insurance Database 2000 of Taiwan to identify 73,597 patients who visited ambulatory care centers or were hospitalized with a first-time diagnosis of anxiety, affective disorders, or schizophrenia between 2001 and 2003 as the study cohort. We also randomly selected 220,791 enrollees matched with the study cohort for comparison. Each patient was individually tracked for 6 years to identify a subsequent PD diagnosis. Stratified Cox proportional hazard regressions were performed for the analysis. RESULTS: The incidence rate of PD per 1000 person-years was 4.91 (95% confidence interval [CI], 4.71-5.12) and 1.63 (95% CI, 1.56-1.70) for the psychiatric and comparison groups, respectively. Patients with psychiatric illnesses were more vulnerable to developing PD than nonpsychiatric individuals, exhibiting a 2.38-fold increased risk (95% CI, 2.23-2.53) after other covariates were considered. Furthermore, patients with schizophrenia exhibited the highest risk for developing PD. CONCLUSIONS: We suggest effective monitoring of patients with psychiatric disturbances for potential long-term neurodegenerative diseases.
Authors: Ayan Hussein; Christopher A Guevara; Pamela Del Valle; Swati Gupta; Deanna L Benson; George W Huntley Journal: Neuroscientist Date: 2021-05-08 Impact factor: 7.235
Authors: Olav B Smeland; Alexey Shadrin; Shahram Bahrami; Iris Broce; Martin Tesli; Oleksandr Frei; Katrine V Wirgenes; Kevin S O'Connell; Florian Krull; Francesco Bettella; Nils Eiel Steen; Leo Sugrue; Yunpeng Wang; Per Svenningsson; Manu Sharma; Lasse Pihlstrøm; Mathias Toft; Michael O'Donovan; Srdjan Djurovic; Rahul Desikan; Anders M Dale; Ole A Andreassen Journal: Biol Psychiatry Date: 2020-02-08 Impact factor: 13.382