Yi-Chia Wang1, Chia-Wei Lin2, Yu-Tsun Ho2, Ya-Pin Huang3, Shin-Liang Pan4. 1. Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan. 2. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. 3. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Yu-Lin Branch, Yunlin, Taiwan. 4. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: panslcb@gmail.com.
Abstract
BACKGROUND: The association between migraine and the risk of ischemic heart disease (IHD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether young migraineurs are at a higher risk of developing IHD. METHODS: A total of 11,541 subjects aged between 18 and 45 years with at least two ambulatory visits with the principal diagnosis of migraine in 2001 were enrolled in the migraine group. We used a logistic regression model that included age, sex, pre-existing comorbidities, and socioeconomic status as covariates to compute the propensity score. The non-migraine group consisted of 11,541 propensity score-matched, randomly sampled subjects without migraine. The 3-year IHD-free survival rate and the cumulative incidence of IHD were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched by propensity score was used to estimate the effect of migraine on the risk of developing subsequent IHD. RESULTS: The mean age in both groups was 32.3 years. During follow-up, 121 subjects in the migraine group and 55 in the non-migraine group developed IHD. The incidence rate of IHD was 4.56 (95% confidence interval [CI], 3.78 to 5.44) per 1000 person-years in the migraine group and 2.00 (95% CI, 1.51 to 2.61) per 1000 person-years in the non-migraine group. Compared to the non-migraine group, the HR of IHD for the migraine group was 2.50 (95% CI, 1.78 to 3.52, P<0.0001). CONCLUSIONS: This study showed an increased risk of developing IHD in young patients with newly diagnosed migraine.
BACKGROUND: The association between migraine and the risk of ischemic heart disease (IHD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether young migraineurs are at a higher risk of developing IHD. METHODS: A total of 11,541 subjects aged between 18 and 45 years with at least two ambulatory visits with the principal diagnosis of migraine in 2001 were enrolled in the migraine group. We used a logistic regression model that included age, sex, pre-existing comorbidities, and socioeconomic status as covariates to compute the propensity score. The non-migraine group consisted of 11,541 propensity score-matched, randomly sampled subjects without migraine. The 3-year IHD-free survival rate and the cumulative incidence of IHD were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched by propensity score was used to estimate the effect of migraine on the risk of developing subsequent IHD. RESULTS: The mean age in both groups was 32.3 years. During follow-up, 121 subjects in the migraine group and 55 in the non-migraine group developed IHD. The incidence rate of IHD was 4.56 (95% confidence interval [CI], 3.78 to 5.44) per 1000 person-years in the migraine group and 2.00 (95% CI, 1.51 to 2.61) per 1000 person-years in the non-migraine group. Compared to the non-migraine group, the HR of IHD for the migraine group was 2.50 (95% CI, 1.78 to 3.52, P<0.0001). CONCLUSIONS: This study showed an increased risk of developing IHD in young patients with newly diagnosed migraine.
Authors: Tobias Kurth; Anke C Winter; A Heather Eliassen; Rimma Dushkes; Kenneth J Mukamal; Eric B Rimm; Walter C Willett; JoAnn E Manson; Kathryn M Rexrode Journal: BMJ Date: 2016-05-31
Authors: Ahmed N Mahmoud; Amgad Mentias; Akram Y Elgendy; Abdul Qazi; Amr F Barakat; Marwan Saad; Ala Mohsen; Ahmed Abuzaid; Hend Mansoor; Mohammad K Mojadidi; Islam Y Elgendy Journal: BMJ Open Date: 2018-03-27 Impact factor: 2.692
Authors: Bendik S Winsvold; Christopher P Nelson; Rainer Malik; Padhraig Gormley; Verneri Anttila; Jason Vander Heiden; Katherine S Elliott; Line M Jacobsen; Priit Palta; Najaf Amin; Boukje de Vries; Eija Hämäläinen; Tobias Freilinger; M Arfan Ikram; Thorsten Kessler; Markku Koiranen; Lannie Ligthart; George McMahon; Linda M Pedersen; Christina Willenborg; Hong-Hee Won; Jes Olesen; Ville Artto; Themistocles L Assimes; Stefan Blankenberg; Dorret I Boomsma; Lynn Cherkas; George Davey Smith; Stephen E Epstein; Jeanette Erdmann; Michel D Ferrari; Hartmut Göbel; Alistair S Hall; Marjo-Riitta Jarvelin; Mikko Kallela; Jaakko Kaprio; Sekar Kathiresan; Terho Lehtimäki; Ruth McPherson; Winfried März; Dale R Nyholt; Christopher J O'Donnell; Lydia Quaye; Daniel J Rader; Olli Raitakari; Robert Roberts; Heribert Schunkert; Markus Schürks; Alexandre F R Stewart; Gisela M Terwindt; Unnur Thorsteinsdottir; Arn M J M van den Maagdenberg; Cornelia van Duijn; Maija Wessman; Tobias Kurth; Christian Kubisch; Martin Dichgans; Daniel I Chasman; Chris Cotsapas; John-Anker Zwart; Nilesh J Samani; Aarno Palotie Journal: Neurol Genet Date: 2015-07-02