Literature DB >> 24462089

The detrimental role of glial acidification during ischemia.

Steven A Sloan1, Ben A Barres2.   

Abstract

In this issue of Neuron, Beppu et al. (2014) demonstrate that glial acidification during ischemia contributes to neurotoxicity. Using a suite of in vivo optogenetic tools, the authors are able to exacerbate or attenuate neuronal damage during ischemia with glial acidification or alkalization, respectively.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID: 24462089      PMCID: PMC4429529          DOI: 10.1016/j.neuron.2013.12.032

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  11 in total

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2.  A pH-dependent increase in neuronal glutamate efflux in vitro: possible involvement of ASCT1.

Authors:  Michael D Weiss; Candace Rossignol; Colin Sumners; Kevin J Anderson
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Review 3.  Ischemic cell death in brain neurons.

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4.  Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.

Authors:  J W Olney
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5.  Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.

Authors:  J W Phillis; J Ren; M H O'Regan
Journal:  Brain Res       Date:  2000-06-16       Impact factor: 3.252

6.  1,026 experimental treatments in acute stroke.

Authors:  Victoria E O'Collins; Malcolm R Macleod; Geoffrey A Donnan; Laura L Horky; Bart H van der Worp; David W Howells
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Review 7.  Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists.

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Journal:  Curr Opin Pharmacol       Date:  2005-12-15       Impact factor: 5.547

Review 8.  Calcium, ischemia and excitotoxicity.

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9.  Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage.

Authors:  Kaoru Beppu; Takuya Sasaki; Kenji F Tanaka; Akihiro Yamanaka; Yugo Fukazawa; Ryuichi Shigemoto; Ko Matsui
Journal:  Neuron       Date:  2014-01-22       Impact factor: 17.173

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Authors:  Georg Nagel; Tanjef Szellas; Wolfram Huhn; Suneel Kateriya; Nona Adeishvili; Peter Berthold; Doris Ollig; Peter Hegemann; Ernst Bamberg
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  7 in total

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4.  Pitfalls of Commonly Used Ischemic and Dementia Models Due to Early Seizure by Carotid Ligation.

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Review 6.  Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters.

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Review 7.  Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage.

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  7 in total

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