José Antonio Gimeno Orna1, Yolanda Blasco Lamarca2, Belén Campos Gutierrez3, Edmundo Molinero Herguedas3, Luis Miguel Lou Arnal4. 1. Servicio Endocrinología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address: jagimeno@salud.aragon.es. 2. Servicio Endocrinología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. 3. Servicio Medicina Interna, Hospital Comarcal de Alcañiz, Alcañiz, Teruel, España. 4. Servicio Nefrología, Hospital Universitario Miguel Servet, Zaragoza, España.
Abstract
INTRODUCTION: This study was aimed to assess the prognostic importance of diabetes duration to predict cardiovascular risk in type 2 diabetic patients. METHODS: Prospective cohort study with inclusion of type 2 diabetic patients. Follow-up lasted until the appearance of a cardiovascular event, until death or until 2012. Patients were classified into 5 groups in accordance to diabetes duration and baseline cardiovascular disease (CVD): group 1: ≤ 5 years without CVD; group 2: 6-10 years without CVD; group 3: 11-15 years without CVD; group 4: >15 years without CVD; group 5: baseline CVD independently of diabetes duration. CVD rates were expressed per 1000 patients-year and compared by Kaplan-Meier analysis and Log Rank Test. The predictive power of diabetes duration was evaluated by Cox regression. RESULTS: 457 patients, aged 64.9 (DE 9.3) years (38.9% males), were included. Diabetes duration was 10.5 (DE 7.6) years. 125 cardiovascular events occurred during 12.3 years follow-up. Cardiovascular event rates were progressively increased from groups 1 to 5 (group 1: 14.1; group 2: 18.3; group 3: 19.6; group 4: 32.9; group 5: 53.5; p<0.0001, linear tendency). Diabetes duration superior to 15 years significantly increased cardiovascular risk of the patients (HR=1.97; 95%CI: 1.23-3.15; P=.004). CONCLUSIONS: It could be useful to consider diabetes duration in order to stratify cardiovascular risk of type 2 diabetic patients.
INTRODUCTION: This study was aimed to assess the prognostic importance of diabetes duration to predict cardiovascular risk in type 2 diabeticpatients. METHODS: Prospective cohort study with inclusion of type 2 diabeticpatients. Follow-up lasted until the appearance of a cardiovascular event, until death or until 2012. Patients were classified into 5 groups in accordance to diabetes duration and baseline cardiovascular disease (CVD): group 1: ≤ 5 years without CVD; group 2: 6-10 years without CVD; group 3: 11-15 years without CVD; group 4: >15 years without CVD; group 5: baseline CVD independently of diabetes duration. CVD rates were expressed per 1000 patients-year and compared by Kaplan-Meier analysis and Log Rank Test. The predictive power of diabetes duration was evaluated by Cox regression. RESULTS: 457 patients, aged 64.9 (DE 9.3) years (38.9% males), were included. Diabetes duration was 10.5 (DE 7.6) years. 125 cardiovascular events occurred during 12.3 years follow-up. Cardiovascular event rates were progressively increased from groups 1 to 5 (group 1: 14.1; group 2: 18.3; group 3: 19.6; group 4: 32.9; group 5: 53.5; p<0.0001, linear tendency). Diabetes duration superior to 15 years significantly increased cardiovascular risk of the patients (HR=1.97; 95%CI: 1.23-3.15; P=.004). CONCLUSIONS: It could be useful to consider diabetes duration in order to stratify cardiovascular risk of type 2 diabeticpatients.