Michael Duruisseaux1, Martine Antoine2, Nathalie Rabbe3, Virginie Poulot4, Jocelyne Fleury-Feith5, Thibault Vieira1, Armelle Lavolé6, Jacques Cadranel3, Marie Wislez7. 1. ER2 UPMC/GRC-UPMC04 Theranoscan, Université Pierre et Marie Curie Paris 6, Paris, France. 2. ER2 UPMC/GRC-UPMC04 Theranoscan, Université Pierre et Marie Curie Paris 6, Paris, France; Service d'Anatomie pathologique, Hôpital Tenon, AP-HP, Paris, France. 3. ER2 UPMC/GRC-UPMC04 Theranoscan, Université Pierre et Marie Curie Paris 6, Paris, France; Service de Pneumologie, Hôpital Tenon, AP-HP, Paris, France. 4. ER2 UPMC/GRC-UPMC04 Theranoscan, Université Pierre et Marie Curie Paris 6, Paris, France; Plateforme de Génomique des Tumeurs Solides, Hôpital Tenon, AP-HP, Paris, France. 5. Service d'Histologie et de Biologie Tumorale, Hôpital Tenon, AP-HP, Paris, France. 6. Service de Pneumologie, Hôpital Tenon, AP-HP, Paris, France. 7. ER2 UPMC/GRC-UPMC04 Theranoscan, Université Pierre et Marie Curie Paris 6, Paris, France; Service de Pneumologie, Hôpital Tenon, AP-HP, Paris, France. Electronic address: marie.wislez@tnn.aphp.fr.
Abstract
OBJECTIVES: This study investigated the clinical and prognostic impact of intracytoplasmic mucin in lung adenocarcinoma with "pneumonic" radiological presentation, formerly known as bronchioloalveolar carcinoma (BAC). PATIENTS AND METHODS: Between 1986 and 2011, clinical and pathological data from 120 consecutive patients with lung adenocarcinoma with "pneumonic" radiological presentation were reviewed. Intracytoplasmic mucin was assessed using a diastase-resistant periodic acid-Schiff staining. The presence of EGFR or K-Ras mutations and ALK rearrangement were determined in surgical samples. RESULTS: The two predominant histological patterns were invasive mucinous adenocarcinoma (40%) and lepidic predominant adenocarcinoma (32%). Intracytoplasmic mucin was detected in 71 patients (59.2%) who were more likely to be non-smokers (p=0.04) and have bronchorrhea (p=0.006), crepitant rales (p=0.02), or neutrophil alveolitis (p=0.0004). In mucin-producing tumors, EGFR mutation was not detected, K-Ras mutations and ALK rearrangement were present in 32% and 3% of cases, respectively. In non-mucin-producing tumors, EGFR and K-Ras mutations were detected in 17% and 10% of cases, respectively, no ALK rearrangement was detected. In univariate analysis, performance status>0, crepitant rales, bronchorrhea, neutrophil alveolitis, bilateral extension, intracytoplasmic mucin and no surgery were associated with worse survival. In multivariate analyses, intracytoplasmic mucin, neutrophil alveolitis, and no surgery were independent factors for worse survival. CONCLUSION: Intracytoplasmic mucin is associated with specific clinical characteristics and is an independent factor for worse survival in lung adenocarcinoma formerly known as BAC.
OBJECTIVES: This study investigated the clinical and prognostic impact of intracytoplasmic mucin in lung adenocarcinoma with "pneumonic" radiological presentation, formerly known as bronchioloalveolar carcinoma (BAC). PATIENTS AND METHODS: Between 1986 and 2011, clinical and pathological data from 120 consecutive patients with lung adenocarcinoma with "pneumonic" radiological presentation were reviewed. Intracytoplasmic mucin was assessed using a diastase-resistant periodic acid-Schiff staining. The presence of EGFR or K-Ras mutations and ALK rearrangement were determined in surgical samples. RESULTS: The two predominant histological patterns were invasive mucinous adenocarcinoma (40%) and lepidic predominant adenocarcinoma (32%). Intracytoplasmic mucin was detected in 71 patients (59.2%) who were more likely to be non-smokers (p=0.04) and have bronchorrhea (p=0.006), crepitant rales (p=0.02), or neutrophil alveolitis (p=0.0004). In mucin-producing tumors, EGFR mutation was not detected, K-Ras mutations and ALK rearrangement were present in 32% and 3% of cases, respectively. In non-mucin-producing tumors, EGFR and K-Ras mutations were detected in 17% and 10% of cases, respectively, no ALK rearrangement was detected. In univariate analysis, performance status>0, crepitant rales, bronchorrhea, neutrophil alveolitis, bilateral extension, intracytoplasmic mucin and no surgery were associated with worse survival. In multivariate analyses, intracytoplasmic mucin, neutrophil alveolitis, and no surgery were independent factors for worse survival. CONCLUSION: Intracytoplasmic mucin is associated with specific clinical characteristics and is an independent factor for worse survival in lung adenocarcinoma formerly known as BAC.
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