| Literature DB >> 2446096 |
P Coursaget1, B Yvonnet, C Bourdil, M N Mevelec, P Adamowicz, J L Barrès, J Chotard, R N'Doye, I Diop Mar, J P Chiron.
Abstract
A viral infection characterised by serum HBsAg positivity with serum anti-HBc negativity has been encountered in Senegal. The infection is not associated with the presence of HBeAg, so it differs from hepatitis B virus in its core antigen, but the surface antigen of the two viruses share some epitopes. After the loss of HBsAg, neither anti-HBc nor anti-HBs becomes detectable. Anti-HBs, naturally acquired or produced by immunisation, does not protect against this new infection. Chronic carriage occurs. If this new infection is confirmed to cause chronic liver disease, hepatitis B vaccine should include surface antigen from the new virus.Entities:
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Year: 1987 PMID： 2446096 DOI： 10.1016/s0140-6736(87)91255-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321