Literature DB >> 24457485

Innate immunity to Toxoplasma gondii infection.

Felix Yarovinsky1.   

Abstract

Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T. gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell-mediated immunity to intracellular infections. However, recent discoveries have shown that innate type 1 immune responses that involve interferon-γ (IFNγ)-producing natural killer (NK) cells and neutrophils, rather than IFNγ-producing T cells, predetermine host resistance to T. gondii. This Review summarizes the Toll-like receptor (TLR)-dependent mechanisms that are responsible for parasite recognition and for the induction of IFNγ production by NK cells, as well as the emerging data about the TLR-independent mechanisms that lead to the IFNγ-mediated elimination of T. gondii.

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Year:  2014        PMID： 24457485     DOI： 10.1038/nri3598

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  154 in total

1.  Role of TNF and IL-1 in infections with Toxoplasma gondii.

Authors:  H R Chang; G E Grau; J C Pechère
Journal:  Immunology       Date:  1990-01       Impact factor: 7.397

2.  In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

Authors:  T M Scharton-Kersten; T A Wynn; E Y Denkers; S Bala; E Grunvald; S Hieny; R T Gazzinelli; A Sher
Journal:  J Immunol       Date:  1996-11-01       Impact factor: 5.422

3.  Macrophage oxidative metabolism and intracellular Toxoplasma gondii.

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Journal:  Microb Pathog       Date:  1989-07       Impact factor: 3.738

4.  Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis.

Authors:  M Deckert-Schlüter; H Bluethmann; A Rang; H Hof; D Schlüter
Journal:  J Immunol       Date:  1998-04-01       Impact factor: 5.422

5.  Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Authors:  R T Gazzinelli; S Hieny; T A Wynn; S Wolf; A Sher
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Authors:  Douglas C Wilson; Gijsbert M Grotenbreg; Kenian Liu; Yanlin Zhao; Eva-Maria Frickel; Marc-Jan Gubbels; Hidde L Ploegh; George S Yap
Journal:  PLoS Pathog       Date:  2010-03-19       Impact factor: 6.823

7.  Activation of tissue macrophages from AIDS patients: in vitro response of AIDS alveolar macrophages to lymphokines and interferon-gamma.

Authors:  H W Murray; R A Gellene; D M Libby; C D Rothermel; B Y Rubin
Journal:  J Immunol       Date:  1985-10       Impact factor: 5.422

8.  Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy.

Authors:  Carl G Feng; Lixin Zheng; Michael J Lenardo; Alan Sher
Journal:  Autophagy       Date:  2009-02-19       Impact factor: 16.016

9.  Interleukin-12 enhances murine survival against acute toxoplasmosis.

Authors:  I A Khan; T Matsuura; L H Kasper
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

10.  Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii.

Authors:  Beena John; Tajie H Harris; Elia D Tait; Emma H Wilson; Beth Gregg; Lai Guan Ng; Paulus Mrass; David S Roos; Florence Dzierszinski; Wolfgang Weninger; Christopher A Hunter
Journal:  PLoS Pathog       Date:  2009-07-03       Impact factor: 6.823
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  144 in total

Review 1.  The molecular biology and immune control of chronic Toxoplasma gondii infection.

Authors:  Xiao-Yu Zhao; Sarah E Ewald
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

2.  Mycophenolic acid induces differentiation of Toxoplasma gondii RH strain tachyzoites into bradyzoites and formation of cyst-like structure in vitro.

Authors:  Kitzia N Castro-Elizalde; Pedro Hernández-Contreras; Carlos J Ramírez-Flores; Sirenia González-Pozos; Carmen T Gómez de León; Mónica Mondragón-Castelán; Ricardo Mondragón-Flores
Journal:  Parasitol Res       Date:  2018-01-08       Impact factor: 2.289

3.  Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.

Authors:  David A Christian; Anita A Koshy; Morgan A Reuter; Michael R Betts; John C Boothroyd; Christopher A Hunter
Journal:  Infect Immun       Date:  2014-07-14       Impact factor: 3.441

4.  Toxoplasma: Immunity and Pathogenesis.

Authors:  Imtiaz A Khan; Charlotte Ouellette; Keer Chen; Magali Moretto
Journal:  Curr Clin Microbiol Rep       Date:  2019-02-04

Review 5.  Toxoplasma Effectors Targeting Host Signaling and Transcription.

Authors:  Mohamed-Ali Hakimi; Philipp Olias; L David Sibley
Journal:  Clin Microbiol Rev       Date:  2017-07       Impact factor: 26.132

6.  Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia.

Authors:  Faith Dickerson; Cassie Stallings; Andrea Origoni; Jennifer Schroeder; Emily Katsafanas; Lucy Schweinfurth; Christina Savage; Sunil Khushalani; Robert Yolken
Journal:  Schizophr Bull       Date:  2015-08-19       Impact factor: 9.306

Review 7.  Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection.

Authors:  Carolyn R Sturge; Felix Yarovinsky
Journal:  Infect Immun       Date:  2014-05-27       Impact factor: 3.441

8.  High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

Authors:  Joshua B Radke; Kimberly L Carey; Subrata Shaw; Shailesh R Metkar; Carol Mulrooney; Jennifer P Gale; Joshua A Bittker; Robert Hilgraf; Eamon Comer; Stuart L Schreiber; Herbert W Virgin; Jose R Perez; L David Sibley
Journal:  ACS Infect Dis       Date:  2018-08-28       Impact factor: 5.084

9.  Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum.

Authors:  Rachel S Coombs; Matthew L Blank; Elizabeth D English; Yaw Adomako-Ankomah; Ifeanyi-Chukwu Samuel Urama; Andrew T Martin; Felix Yarovinsky; Jon P Boyle
Journal:  Infect Immun       Date:  2020-03-23       Impact factor: 3.441

Review 10.  Colonization and effector functions of innate lymphoid cells in mucosal tissues.

Authors:  Myunghoo Kim; Chang H Kim
Journal:  Microbes Infect       Date:  2016-06-27       Impact factor: 2.700
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