Literature DB >> 24456660

Bioactive phthalides from Ligusticum sinense Oliv cv. Chaxiong.

Qian Wei1, Jianbo Yang2, Jin Ren2, Aiguo Wang2, Tengfei Ji2, Yalun Su3.   

Abstract

Five new phthalides (1-4, 6), two new natural products (5, 7) and five known phthalides (8-12) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were established by the circular dichroism (CD) spectrum and the modified Mosher's method. Compounds 1-8 were tested against SK-N-SH cell depriving oxygen and glucose and showed different degrees of increasing the cell survival, among which compounds 1, 4 and 8 (10 μM) showed higher cell survival than Ginsenoside Rg1.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aerial parts; CD; Ligusticum sinense Oliv cv. Chaxiong; Modified Mosher's method; Neuronal impairment protective effect; Phthalide

Mesh：

Substances：

Year:  2014        PMID： 24456660     DOI： 10.1016/j.fitote.2014.01.010

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  4 in total

1.  Characterization of the complete chloroplast genome of Ligusticum sinense, as a Chinese herb to treat toothache in China.

Authors:  Qingwei Wu; Hui Wu; Li-Kang Wang; Xin Zhao
Journal:  Mitochondrial DNA B Resour       Date:  2020-08-17       Impact factor: 0.658

2.  Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound.

Authors:  Peng-Yi Hu; Ying-Huai Zhong; Jian-Fang Feng; Dong-Xun Li; Ping Deng; Wen-Liu Zhang; Zhi-Qiang Lei; Xue-Mei Liu; Guo-Song Zhang
Journal:  BMC Complement Med Ther       Date:  2021-04-22

3.  Three New Phthalide Glycosides from the Rhizomes of Cnidium officinale and Their Recovery Effect on Damaged Otic Hair Cells in Zebrafish.

Authors:  Hyoung-Geun Kim; Seon Min Oh; Na Woo Kim; Ji Heon Shim; Youn Hee Nam; Trong Nguyen Nguyen; Min-Ho Lee; Dae Young Lee; Tong Ho Kang; Nam-In Baek
Journal:  Molecules       Date:  2021-11-21       Impact factor: 4.411

4.  Remarkable repellency of Ligusticum sinense (Umbelliferae), a herbal alternative against laboratory populations of Anopheles minimus and Aedes aegypti (Diptera: Culicidae).

Authors:  Rukpong Sanghong; Anuluck Junkum; Udom Chaithong; Atchariya Jitpakdi; Doungrat Riyong; Benjawan Tuetun; Daruna Champakaew; Jitrawadee Intirach; Roongtawan Muangmoon; Arpaporn Chansang; Benjawan Pitasawat
Journal:  Malar J       Date:  2015-08-07       Impact factor: 2.979
  4 in total

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