Literature DB >> 2445601

A monoclonal antibody against a synthetic peptide reveals common structures among spectrins and alpha-actinin.

O Närvänen1, A Närvänen, V M Wasenius, P Partanen, I Virtanen.   

Abstract

A monoclonal antibody (Mab) against a synthetic peptide, SEDYGKDL, corresponding to one conserved sequence in the chicken alpha-fodrin repeats reacts in immunoblotting with avian alpha-spectrin and alpha-fodrin, both mammalian spectrins and with mammalian alpha-fodrin. This Mab also reacts with alpha-actinin in both chicken and human cells. Our results confirm the previously detected structural homology between spectrins and alpha-actinin and implicate their common evolutionary origin.

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Year:  1987        PMID: 2445601     DOI: 10.1016/0014-5793(87)80440-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  3 in total

1.  Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.

Authors:  H Youssoufian; M McAfee; D J Kwiatkowski
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025

Review 2.  The structure and function of alpha-actinin.

Authors:  A Blanchard; V Ohanian; D Critchley
Journal:  J Muscle Res Cell Motil       Date:  1989-08       Impact factor: 2.698

3.  Primary structure of the brain alpha-spectrin.

Authors:  V M Wasenius; M Saraste; P Salvén; M Erämaa; L Holm; V P Lehto
Journal:  J Cell Biol       Date:  1989-01       Impact factor: 10.539

  3 in total

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