Literature DB >> 24453597

Study of tibial nerve regeneration in Wistar rats in primary neurorrhaphy with and without gap, wrapped in vein segments.

Ewerton Bastos Dos Santos1, Marcela Fernandes1, João Baptista Gomes Dos Santos1, Vilnei Mattioli Leite1, Sandra Gomes Valente1, Flávio Faloppa1.   

Abstract

OBJECTIVE: This study compared nerve regeneration in Wistar rats, using epineural neurorrhaphy with a gap of 1.0 mm and without a gap, both wrapped with jugular vein tubes. Motor neurons in the spinal cord between L3 and S1 were used for the count, marked by exposure of the tibial nerve to Fluoro-Gold (FG).
METHOD: The tibial nerves on both sides were cut and sutured, with a gap on one side and no gap in the other. The sutures were wrapped with a jugular vein. Four months after surgery the tibial nerves were exposed to Fluoro-Gold and the motor neuron count performed in the spinal cord.
RESULTS: The results were statistically analyzed by the paired Wilcoxon test. There was a statistical difference between the groups with and without gap in relation to the motor neuron count (p=0.013).
CONCLUSION: The epineural neurorraphy without gap wrapped with jugular vein showed better results for nerve regeneration than the same procedure with gap. LEVEL OF EVIDENCE: Experimental Study .

Entities:  

Keywords:  Fluorescent dyes; Nerve regeneration; Suture techniques; Tibial nerve; Wistar rats

Year:  2012        PMID: 24453597      PMCID: PMC3718436          DOI: 10.1590/S1413-78522012000300006

Source DB:  PubMed          Journal:  Acta Ortop Bras        ISSN: 1413-7852            Impact factor:   0.513


  19 in total

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2.  Collagencontent of rabbit sciatic nerve during Wallerian degeneration.

Authors:  M ABERCROMBIE; M L JOHNSON
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3.  Preferential motor reinnervation: a sequential double-labeling study.

Authors:  T M Brushart
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Review 4.  Nerve regeneration through artificial tubular implants.

Authors:  R D Fields; J M Le Beau; F M Longo; M H Ellisman
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5.  Inside-out vein graft promotes improved nerve regeneration in rats.

Authors:  K K Wang; P D Costas; D J Bryan; D S Jones; B R Seckel
Journal:  Microsurgery       Date:  1993       Impact factor: 2.425

6.  Nerve regeneration through synthetic biodegradable nerve guides: regulation by the target organ.

Authors:  B R Seckel; T H Chiu; E Nyilas; R L Sidman
Journal:  Plast Reconstr Surg       Date:  1984-08       Impact factor: 4.730

7.  Autogenous vein graft as a conduit for nerve regeneration.

Authors:  D T Chiu; I Janecka; T J Krizek; M Wolff; R E Lovelace
Journal:  Surgery       Date:  1982-02       Impact factor: 3.982

8.  Vein, silastic, and polyglycolic acid fine mesh: a comparative study in peripheral nerve repair.

Authors:  R D Lolley; W J Bose; F Bastian; B Bassam; F N Meyer; L D Anderson
Journal:  Ann Plast Surg       Date:  1995-09       Impact factor: 1.539

9.  The use of fluorescent tracers in the peripheral sensory nervous system.

Authors:  D C Taylor; F K Pierau; H Schmid
Journal:  J Neurosci Methods       Date:  1983-07       Impact factor: 2.390

10.  Tropism in nerve regeneration in vivo. Attraction of regenerating axons by diffusible factors derived from cells in distal nerve stumps of transected peripheral nerves.

Authors:  M J Politis; K Ederle; P S Spencer
Journal:  Brain Res       Date:  1982-12-16       Impact factor: 3.252

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  2 in total

Review 1.  Peripheral nerve regeneration with conduits: use of vein tubes.

Authors:  Rodrigo Guerra Sabongi; Marcela Fernandes; João Baptista Gomes Dos Santos
Journal:  Neural Regen Res       Date:  2015-04       Impact factor: 5.135

2.  Bone marrow mesenchymal stem cell and vein conduit on sciatic nerve repair in rats.

Authors:  Kamal Seyed Foroutan; Ali Khodarahmi; Hootan Alavi; Sepehr Pedram; Mohamad Reza Baghaban Eslaminejad; Sima Bordbar
Journal:  Trauma Mon       Date:  2015-01-17
  2 in total

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