Shaloom D'Silva1, M K Sumathi2, N Balaji2, Nisha K N Shetty3, K M Pramod4, Jacob Cheeramelil5. 1. Doha, Qatar. 2. Department of Oral & Maxillofacial Pathology, Teerthankar Mahaveer Dental College and Research Centre, Teerthankar Mahaveer University, Moradabad, Uttar Pradesh, India. 3. Department of Oral & Maxillofacial Surgery, Career Dental College & Hospital, Lucknow, Uttar Pradesh, India. 4. Department of Orthodontics, D A P M R V Dental College, Bangalore, Karnataka, India. 5. Department of Orthodontics, Annoor Dental College, Muvattupuzha, Kerala, India.
Abstract
BACKGROUND: Calretinin a 29-kDa calcium binding protein is expressed widely in normal human tissue and tumours including amelobastoma. The objective of this study was to determine calretinin expression in heamatoxylin and eosin diagnosed cases of ameloblastoma and non-neoplastic odontogenic cysts. MATERIALS & METHODS: The lining epithelium in 3 cases of radicular cysts, 5 cases of odontogenic keratocysts, 5 cases of dentigerous cysts and 11 cases of ameloblastomas were examined for expression of calretinin. RESULTS: No positive epithelial staining was observed in radicular and dentigerous cysts. In comparison, however 100% of cases of ameloblastomas and 40% of cases of odontogenic karatocysts showed positive calretinin expression. CONCLUSION: Calretinin may be a specific immunohistochemical marker for ameloblastoma. If there is any possible relation between calretinin expression and neural origin of the odontogenic epithelium and its neoplastic transformation and if calretinin could be used as an early marker to predict the tendency of neoplastic change of odontogenic epithelium could be answered through further researches. How to cite this article: D'Silva S, Sumathi MK, Balaji N, Shetty NK, Pramod KM, Cheeramelil J. Evaluation of Calretinin expression in Ameloblastoma and Non-Neoplastic Odontogenic Cysts - An immunohistochemical study. J Int Oral Health 2013; 5(6):42-8 .
BACKGROUND:Calretinin a 29-kDa calcium binding protein is expressed widely in normal human tissue and tumours including amelobastoma. The objective of this study was to determine calretinin expression in heamatoxylin and eosin diagnosed cases of ameloblastoma and non-neoplastic odontogenic cysts. MATERIALS & METHODS: The lining epithelium in 3 cases of radicular cysts, 5 cases of odontogenic keratocysts, 5 cases of dentigerous cysts and 11 cases of ameloblastomas were examined for expression of calretinin. RESULTS: No positive epithelial staining was observed in radicular and dentigerous cysts. In comparison, however 100% of cases of ameloblastomas and 40% of cases of odontogenic karatocysts showed positive calretinin expression. CONCLUSION:Calretinin may be a specific immunohistochemical marker for ameloblastoma. If there is any possible relation between calretinin expression and neural origin of the odontogenic epithelium and its neoplastic transformation and if calretinin could be used as an early marker to predict the tendency of neoplastic change of odontogenic epithelium could be answered through further researches. How to cite this article: D'Silva S, Sumathi MK, Balaji N, Shetty NK, Pramod KM, Cheeramelil J. Evaluation of Calretinin expression in Ameloblastoma and Non-Neoplastic Odontogenic Cysts - An immunohistochemical study. J Int Oral Health 2013; 5(6):42-8 .
Authors: Liam Robinson; Chané Smit; Felipe Paiva Fonseca; Aline Corrêa Abrahão; Mário José Romañach; Syed Ali Khurram; Keith D Hunter; Paul M Speight; Willie F P van Heerden Journal: Head Neck Pathol Date: 2022-07-21