| Literature DB >> 24453171 |
Shuhei Uesugi1, Zhao Li, Ryo Yazaki, Takashi Ohshima.
Abstract
A highly chemoselective conjugate addition of alcohols in the presence of amines is described. The cooperative nature of the catalyst enabled chemoselective activation of alcohols over amines, allowing the conjugate addition to soft Lewis basic α,β-unsaturated nitriles. Divergent transformation of the nitrile functionality highlights the utility of the present catalysis.Entities:
Keywords: amino alcohols; chemoselective catalysis; cooperative effects; proton transfer; synthetic methods
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Year: 2014 PMID： 24453171 DOI： 10.1002/anie.201309755
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336