Literature DB >> 24452991

Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois Poison Center, 2001-2011.

Jamie E Ehrenpreis1, Carol DesLauriers, Patrick Lank, P Keelan Armstrong, Jerrold B Leikin.   

Abstract

Nutmeg is a commonly consumed spice. The toxic effects of nutmeg have been purported to be due mainly to myristicin oil. Prior poison center series of nutmeg exposures show very few unintentional exposures of nutmeg to children younger than 13. Case series from these centers did not record drug exposures combined with nutmeg. This study is a review of Illinois Poison Center (IPC) data regarding nutmeg exposures from January of 2001 to December 2011. The goal of this study was to compare the Illinois data to the literature as well as look for current trends in nutmeg poisonings. The data were extracted using the code for hallucinogenic plants in the IPC database, and poisonings unrelated to nutmeg exposure were eliminated. Medical outcomes were noted as recorded. Thirty-two cases of nutmeg ingestion were reported. Of the 17 (53.1 %) unintentional exposures, 10 subjects (58.8 %) were under the age of 13. Four of the exposures in children under the age of 13 were ocular exposures. Fifteen exposures (46.9 %) were intentional exposures. Of these intentional exposures, five (33.3 %) were recorded to have combined drug intoxication. All of these were between the ages of 15 and 20. One patient with polypharmaceutical exposure required ventilatory support in the hospital. Our study shows an unexpected percentage of unintentional exposures in juveniles under the age of 13, out of the total exposures to nutmeg. Mixing of nutmeg with other drugs was seen and required more intervention in adolescents. More education about these two factors, i.e., nutmeg exposures as intentional polypharmacy in adolescents and unintentional exposures in young children, is advised.

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Year:  2014        PMID: 24452991      PMCID: PMC4057546          DOI: 10.1007/s13181-013-0379-7

Source DB:  PubMed          Journal:  J Med Toxicol        ISSN: 1556-9039


  14 in total

1.  Poison center data accuracy: a comparison of rural hospital chart data with the TESS database. Toxic Exposure Surveillance System.

Authors:  B T Hoyt; R Rasmussen; S Giffin; M J Smilkstein
Journal:  Acad Emerg Med       Date:  1999-08       Impact factor: 3.451

2.  Nutmeg intoxication.

Authors:  G I Quin; N F Fanning; P K Plunkett
Journal:  J Accid Emerg Med       Date:  1998-07

Review 3.  Duloxetine Eli Lilly & Co.

Authors:  N Pitsikas
Journal:  Curr Opin Investig Drugs       Date:  2000-09

4.  Pharmacokinetics and side-effects of clonazepam and its 7-amino-metabolite in man.

Authors:  O Sjö; E F Hvidberg; J Naestoft; M Lund
Journal:  Eur J Clin Pharmacol       Date:  1975-04-04       Impact factor: 2.953

5.  Low cost, high risk: accidental nutmeg intoxication.

Authors:  A K Demetriades; P D Wallman; A McGuiness; M C Gavalas
Journal:  Emerg Med J       Date:  2005-03       Impact factor: 2.740

6.  Poisoning mortality in the United States: comparison of national mortality statistics and poison control center reports.

Authors:  J M Hoppe-Roberts; L M Lloyd; P A Chyka
Journal:  Ann Emerg Med       Date:  2000-05       Impact factor: 5.721

7.  Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre.

Authors:  U Stein; H Greyer; H Hentschel
Journal:  Forensic Sci Int       Date:  2001-04-15       Impact factor: 2.395

8.  Underreporting of fatal cases to a regional poison control center.

Authors:  P D Blanc; T E Kearney; K R Olson
Journal:  West J Med       Date:  1995-06

Review 9.  Benzodiazepine side effects: role of pharmacokinetics and pharmacodynamics.

Authors:  A N Vgontzas; A Kales; E O Bixler
Journal:  Pharmacology       Date:  1995-10       Impact factor: 2.547

10.  Chronic nutmeg psychosis.

Authors:  N Brenner; O S Frank; E Knight
Journal:  J R Soc Med       Date:  1993-03       Impact factor: 18.000

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  5 in total

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Journal:  J Food Sci Technol       Date:  2017-11-04       Impact factor: 2.701

2.  Effects of blanching and pickling process on the alcohol acyltransferase (AAT) activity, myristicin content and quality parameters of pickled nutmeg (Myristica fragrans).

Authors:  Nurain Rahman; Kaiser Mahmood; Hanisah Kamilah; Syazana Sulaiman; Muhammad Ibrahim; Fazilah Ariffin
Journal:  J Food Sci Technol       Date:  2021-02-24       Impact factor: 2.701

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4.  Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.

Authors:  Wei Kevin Zhang; Shan-Shan Tao; Ting-Ting Li; Yu-Sang Li; Xiao-Jun Li; He-Bin Tang; Ren-Huai Cong; Fang-Li Ma; Chu-Jun Wan
Journal:  Food Nutr Res       Date:  2016-04-26       Impact factor: 3.894

5.  The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity.

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Journal:  Foods       Date:  2020-01-02
  5 in total

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