Literature DB >> 2445256

Inactive X chromosome gene reactivation induced by 5-azacytidine, is not correlated with the modification of the pattern of replication.

M C Hors-Cayla1, J Couturier, N Homman, S Heuertz, J Frézal.   

Abstract

The replication pattern of a human inactive X chromosome reactivated for one to four genes by 5-azacytidine has been studied by the BrdU-33258-Hoechst-Giemsa technique in four subclones of a somatic hamster-human hybrid. In one of them the pattern was clearly modified. In the three others the changes were not significant. No correlation was found between expression and replication.

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Year:  1987        PMID： 2445256

Source DB:  PubMed          Journal:  Ann Genet        ISSN： 0003-3995


  2 in total

1.  DNase I sensitivity of Microtus agrestis active, inactive and reactivated X chromosomes in mouse-Microtus cell hybrids.

Authors:  B S Kerem; V Kottusch-Geiseler; V Kalscheuer; R Goitein; K Sperling; M Marcus
Journal:  Chromosoma       Date:  1988       Impact factor: 4.316

2.  Inhibition of condensation in the late-replicating X chromosome induced by 5-azadeoxycytidine in human lymphocyte cultures.

Authors:  T Haaf; G Ott; M Schmid
Journal:  Hum Genet       Date:  1988-05       Impact factor: 4.132
  2 in total

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