PURPOSE: Estimation of skeletal muscle metastases (SMMs) at the time of diagnosis and/or initial staging of lung cancer. MATERIALS AND METHODS: Retrospective evaluation of clinical charts and imaging data suggestive of SMMs of patients with histology-proved lung cancer over a 5-year period. RESULTS: SMMs were identified in 46 out of 1,754 patients. Single and multiple (62.9% of cases) SMMs were detected by total body multi-detector computed tomography (MDCT). They were associated with poorly differentiated (43%) and advanced adenocarcinomas (52%) without clinically relevant symptoms and/or signs. Psoas and buttock muscles were most frequently involved (33.3%). MDCT findings consisted of well-defined homogeneously hyperdense oval masses (31%), lesions with ring-like enhancement and central hypoattenuation (68%), or large abscess-like necrotic lesions (24%). Sonography revealed well-defined hypoechoic masses (41.6%), ill-defined hypoechoic lesions (33.3%), or anechoic areas with a necrotic centre (25%). Positron emission tomography revealed that all SMMs were metabolically active. CONCLUSIONS: SMMs are uncommon but not negligible in lung cancer, with an estimated prevalence of 2.62% in our series. Although histology remains the recommended method, use of high-performance imaging techniques and increased clinical suspicion may improve their early detection. Efforts addressing their effect on the natural history of lung cancer are needed.
PURPOSE: Estimation of skeletal muscle metastases (SMMs) at the time of diagnosis and/or initial staging of lung cancer. MATERIALS AND METHODS: Retrospective evaluation of clinical charts and imaging data suggestive of SMMs of patients with histology-proved lung cancer over a 5-year period. RESULTS: SMMs were identified in 46 out of 1,754 patients. Single and multiple (62.9% of cases) SMMs were detected by total body multi-detector computed tomography (MDCT). They were associated with poorly differentiated (43%) and advanced adenocarcinomas (52%) without clinically relevant symptoms and/or signs. Psoas and buttock muscles were most frequently involved (33.3%). MDCT findings consisted of well-defined homogeneously hyperdense oval masses (31%), lesions with ring-like enhancement and central hypoattenuation (68%), or large abscess-like necrotic lesions (24%). Sonography revealed well-defined hypoechoic masses (41.6%), ill-defined hypoechoic lesions (33.3%), or anechoic areas with a necrotic centre (25%). Positron emission tomography revealed that all SMMs were metabolically active. CONCLUSIONS: SMMs are uncommon but not negligible in lung cancer, with an estimated prevalence of 2.62% in our series. Although histology remains the recommended method, use of high-performance imaging techniques and increased clinical suspicion may improve their early detection. Efforts addressing their effect on the natural history of lung cancer are needed.
Authors: M Nishikawa; T Akahori; H Kuriyama; S Kimura; Y Nakatani; N Kakemizu; H Ikeda; T Okubo Journal: Respirology Date: 1997-12 Impact factor: 6.424
Authors: M Hajsalah; N Fajraoui; M H Bouhaouala; S Mourali; R Ben Mefteh; A Ghrissi; K Ben Hamida; K Ben Romdhane; M R Charfi Journal: Rev Pneumol Clin Date: 2007-04
Authors: Tamara Miner Haygood; Mohamed Sayyouh; Jason Wong; Jennifer C Lin; Aurelio Matamoros; Carl Sandler; John E Madewell Journal: Sultan Qaboos Univ Med J Date: 2015-08-24
Authors: Amalia Lupi; Michael Weber; Paolo Del Fiore; Marco Rastrelli; Giuseppe Guglielmi; Roberto Stramare; Emilio Quaia; Diego Cecchin; Chiara Giraudo Journal: Eur Radiol Date: 2019-12-13 Impact factor: 5.315