Frédéric Lioté1, Hang-Korng Ea. 1. aSorbonne Paris Cité, University Paris Diderot bInserm, UMR S606/1332, Centre Viggo Petersen, Hôpital Lariboisière cAP-HP, Hôpital Lariboisière, Pôle Appareil Locomoteur, Service de Rhumatologie A, Centre Viggo Petersen, Paris, France.
Abstract
PURPOSE OF REVIEW: The role of intraarticular calcifications has been challenged over the past years, with respect to cartilage destruction, especially in osteoarthritis. RECENT FINDINGS: Main themes reviewed in this article will discuss prevalence of articular cartilage calcifications, mechanisms of cartilage calcifications, and mostly the pathogenic role of both calcium pyrophosphate and basic calcium phosphate crystals. SUMMARY: A direct pathogenic role of both calcium crystals has been depicted, in cartilage as a crystal-induced stress, or via acute or chronic crystal-induced synovitis.
PURPOSE OF REVIEW: The role of intraarticular calcifications has been challenged over the past years, with respect to cartilage destruction, especially in osteoarthritis. RECENT FINDINGS: Main themes reviewed in this article will discuss prevalence of articular cartilage calcifications, mechanisms of cartilage calcifications, and mostly the pathogenic role of both calcium pyrophosphate and basic calcium phosphate crystals. SUMMARY: A direct pathogenic role of both calcium crystals has been depicted, in cartilage as a crystal-induced stress, or via acute or chronic crystal-induced synovitis.
Authors: Thelonius Hawellek; Jan Hubert; Sandra Hischke; Matthias Krause; Jessica Bertrand; Burkhard C Schmidt; Andreas Kronz; Klaus Püschel; Wolfgang Rüther; Andreas Niemeier Journal: Arthritis Res Ther Date: 2018-05-30 Impact factor: 5.156