Avraham Beigelman1, George M Weinstock, Leonard B Bacharier. 1. aDepartment of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital bThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract
PURPOSE OF REVIEW: Recent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial colonization on the development and the activity of asthma. RECENT FINDINGS: Recent findings continue to support the protective role of early-life diverse microbial exposure against the development of atopic diseases. However, airway bacterial colonization early in life serves as a risk factor for the development of asthma. Culture-independent molecular techniques for the identification of microorganisms have challenged the traditional paradigm that the lower airway is a sterile compartment. Asthmatics, compared with nonasthmatics, appear to have a different lung microbiome composition and some of these differences might contribute to asthma activity, severity, and corticosteroid response. SUMMARY: Bacterial presence in the airway appears to influence the inception and may affect the activity of asthma. Complex interactions between different types and routes of bacterial exposures, the airway, and the immune system early in life may determine whether these exposures augment or reduce the risk of asthma development.
PURPOSE OF REVIEW: Recent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial colonization on the development and the activity of asthma. RECENT FINDINGS: Recent findings continue to support the protective role of early-life diverse microbial exposure against the development of atopic diseases. However, airway bacterial colonization early in life serves as a risk factor for the development of asthma. Culture-independent molecular techniques for the identification of microorganisms have challenged the traditional paradigm that the lower airway is a sterile compartment. Asthmatics, compared with nonasthmatics, appear to have a different lung microbiome composition and some of these differences might contribute to asthma activity, severity, and corticosteroid response. SUMMARY: Bacterial presence in the airway appears to influence the inception and may affect the activity of asthma. Complex interactions between different types and routes of bacterial exposures, the airway, and the immune system early in life may determine whether these exposures augment or reduce the risk of asthma development.
Authors: Yvonne J Huang; Emily S Charlson; Ronald G Collman; Sandra Colombini-Hatch; Fernando D Martinez; Robert M Senior Journal: Am J Respir Crit Care Med Date: 2013-06-15 Impact factor: 21.405
Authors: Alison Morris; James M Beck; Patrick D Schloss; Thomas B Campbell; Kristina Crothers; Jeffrey L Curtis; Sonia C Flores; Andrew P Fontenot; Elodie Ghedin; Laurence Huang; Kathleen Jablonski; Eric Kleerup; Susan V Lynch; Erica Sodergren; Homer Twigg; Vincent B Young; Christine M Bassis; Arvind Venkataraman; Thomas M Schmidt; George M Weinstock Journal: Am J Respir Crit Care Med Date: 2013-05-15 Impact factor: 21.405
Authors: Nilofar V Følsgaard; Susanne Schjørring; Bo L Chawes; Morten A Rasmussen; Karen A Krogfelt; Susanne Brix; Hans Bisgaard Journal: Am J Respir Crit Care Med Date: 2013-01-31 Impact factor: 21.405
Authors: Michelle L Husulak; Stephen T Manning; Melissa D Meachem; Hilary J Burgess; Tasha Y Epp; Julia B Montgomery Journal: Can J Vet Res Date: 2018-07 Impact factor: 1.310
Authors: W Gerald Teague; Monica G Lawrence; Debbie-Ann T Shirley; Andrea S Garrod; Stephen V Early; Jackie B Payne; Julia A Wisniewski; Peter W Heymann; James J Daniero; John W Steinke; Deborah K Froh; Thomas J Braciale; Michael Ellwood; Drew Harris; Larry Borish Journal: J Allergy Clin Immunol Pract Date: 2019-01-14
Authors: Jennifer Therkorn; Leonardo Calderon; Benton Cartledge; Nirmala Thomas; Brian Majestic; Gediminas Mainelis Journal: Environ Sci Nano Date: 2018-01-03
Authors: Peter S Thorne; Angelico Mendy; Nervana Metwali; Päivi Salo; Caroll Co; Renee Jaramillo; Kathryn M Rose; Darryl C Zeldin Journal: Am J Respir Crit Care Med Date: 2015-12-01 Impact factor: 21.405
Authors: Velma T E Aho; Pedro A B Pereira; Tari Haahtela; Ruby Pawankar; Petri Auvinen; Kaisa Koskinen Journal: World Allergy Organ J Date: 2015-06-16 Impact factor: 4.084
Authors: Mythili Srinivasan; Leonard B Bacharier; Charles W Goss; Yanjiao Zhou; Jonathan Boomer; Sarah Bram; Dana Burgdorf; Carey-Ann Burnham; Timothy Casper; Mario Castro; Andrea Coverstone; Matthew Haslam; Watcharoot Kanchongkittiphon; Cadence Kuklinski; Qinghua Lian; Kenneth Schechtman; Gregory A Storch; Kelly True; Meghan A Wallace; Huiqing Yin-DeClue; Elizabeth Ahrens; Jinli Wang; Avraham Beigelman Journal: Contemp Clin Trials Commun Date: 2021-06-09